User:Alice Harmon/Sandbox 5: Difference between revisions

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Melcher K, Ng LM, Zhou XE, Soon FF, Xu Y, Suino-Powell KM,Park SY, Weiner JJ, Fujii H, Chinnusamy V, Kovach A, Li
Melcher K, Ng LM, Zhou XE, Soon FF, Xu Y, Suino-Powell KM,Park SY, Weiner JJ, Fujii H, Chinnusamy V, Kovach A, Li
J, Wang Y, Peterson FC, Jensen DR, Yong EL, Volkman BF,Cutler SR, Zhu JK, Xu HE(2009) A gate-latch-lock mechanism for
J, Wang Y, Peterson FC, Jensen DR, Yong EL, Volkman BF,Cutler SR, Zhu JK, Xu HE(2009) A gate-latch-lock mechanism for
hormone signalling by abscisic acid receptors.Nature 462, 602–608.<br>
hormone signalling by abscisic acid receptors.Nature 462, 602–608.<ref>PMID:19898420</ref><br>
Melcher K, Zhou XE, Xu HE (2010) Thirsty plants and beyond: Structural mechanisms of abscisic acid perception and signaling. Curr. Opin. Struct. Biol. 20, 722–729.<br>
Melcher K, Zhou XE, Xu HE (2010) Thirsty plants and beyond: Structural mechanisms of abscisic acid perception and signaling. Curr. Opin. Struct. Biol. 20, 722–729.<ref>PMID:20951573</ref><br>
Miyazono K, Miyakawa T, Sawano Y, Kubota K, Kang HJ, Asano A, Miyauchi Y, Takahashi M, Zhi Y, Fujita Y, Yoshida T, Kodaira KS, Yamaguchi-Shinozaki K, Tanokura M (2009) Structural basis of abscisic acid signalling. Nature 462, 609–614<br>
Miyazono K, Miyakawa T, Sawano Y, Kubota K, Kang HJ, Asano A, Miyauchi Y, Takahashi M, Zhi Y, Fujita Y, Yoshida T, Kodaira KS, Yamaguchi-Shinozaki K, Tanokura M (2009) Structural basis of abscisic acid signalling. Nature 462, 609–614<ref>PMID:19855379</ref><br>
Nishimura N, Hitomi K, Arvai AS, Rambo RP, Hitomi C, Cutler SR,
Nishimura N, Hitomi K, Arvai AS, Rambo RP, Hitomi C, Cutler SR,
Schroeder JI, Getzoff ED (2009) Structural mechanism of abscisic acid binding and signaling by dimeric PYR1. Science 326, 1373–1379<br>
Schroeder JI, Getzoff ED (2009) Structural mechanism of abscisic acid binding and signaling by dimeric PYR1. Science 326, 1373–1379<ref>PMID:19933100</ref><br>
Santiago J, Rodrigues A, Saez A, Rubio S, Antoni R, Dupeux F, Park SY, Marquez JA, Cutler SR, Rodriguez PL (2009b)
Santiago J, Rodrigues A, Saez A, Rubio S, Antoni R, Dupeux F, Park SY, Marquez JA, Cutler SR, Rodriguez PL (2009b)
Modulation of drought resistance by the abscisic acid receptor PYL5 through inhibition of clade A PP2Cs.
Modulation of drought resistance by the abscisic acid receptor PYL5 through inhibition of clade A PP2Cs.
Plant J. 60, 575–588<br>
Plant J. 60, 575–588<ref>PMID:19624469</ref><br>
YinP,FanH,HaoQ,YuanX,WuD,PangY,YanC,LiW,WangJ,Yan N (2009) Structural insights into the mechanism of abscisic acid signaling by PYL proteins. Nat. Struct. Mol. Biol. 16, 1230–1236<br>
YinP,FanH,HaoQ,YuanX,WuD,PangY,YanC,LiW,WangJ,Yan N (2009) Structural insights into the mechanism of abscisic acid signaling by PYL proteins. Nat. Struct. Mol. Biol. 16, 1230–1236<ref>PMID:19893533</ref><br>
 
Structural insights into PYR/PYL/RCAR ABA receptors and PP2Cs.<br>
Santiago J, Dupeux F, Betz K, Antoni R, Gonzalez-Guzman M, Rodriguez L, Márquez JA, Rodriguez PL.Plant Sci. 2012 182:3-11<ref>PMID:22118610</ref>




Revision as of 18:31, 3 October 2013

Pyr/Pyl/RCAR family of ABA receptorsPyr/Pyl/RCAR family of ABA receptors

ABA signaling pathwayABA signaling pathway

Abscisic acid (ABA,)

Abscisic Acid

is a plant hormone that regulates seed dormancy and germination, stomatal closure, and responses to drought stress.[1][2] As shown in the left figure, ABA binds to an ABA receptor (R)[3][4][5]. The activated receptor (R.ABA) binds to a protein phosphatase 2C (R.ABA-P), which was formerly in a complex with a SnRK2 protein kinase. The protein kinase is now free to be activated by autophosphorylation or phosphorylation by another protein kinase. Activation of SnRK2.6/OST1/SRK2E leads to phosphorylation of: 1) ion channels SLAC1[6] and KAT1[7] in guard cells and stomatal closure; 2) transcription factor ABI5[8] in seeds/seedlings and dormancy/growth arrest; or 3) phosphorylation of transcription factor AREB/ABF [9][10] in vegetative tissue and stress tolerance and growth regulation.

The ABA receptor family includes PYR1, PYR2, PYL1, PYL2, and RCAR. The ABA-responsive protein phosphatase 2Cs are in Clade C and they include ABI1, ABI2, and HAB1. The ABA-activated protein kinases are in subclass III of SnRK2s and they include SnRK2.6/OST1/SRK2E, and SNRK2.2/SRK2D and SnRK2.3/SRK2I

Structures in the figure are: R, apo PYR2, 3kdh; R.ABA, PYR2.ABA, 3kdi; K-P; SnRK2.6-HAB1, 3ujg; R.ABA-P, PYR2.ABA-ABI2, 3ujl; K, SnRK2.6,3uc4.

The following Proteopedia pages

crystal structures of PYR1/RCAR11 and PYL9/RCAR1

Melcher K, Ng LM, Zhou XE, Soon FF, Xu Y, Suino-Powell KM,Park SY, Weiner JJ, Fujii H, Chinnusamy V, Kovach A, Li J, Wang Y, Peterson FC, Jensen DR, Yong EL, Volkman BF,Cutler SR, Zhu JK, Xu HE(2009) A gate-latch-lock mechanism for hormone signalling by abscisic acid receptors.Nature 462, 602–608.[11]
Melcher K, Zhou XE, Xu HE (2010) Thirsty plants and beyond: Structural mechanisms of abscisic acid perception and signaling. Curr. Opin. Struct. Biol. 20, 722–729.[12]
Miyazono K, Miyakawa T, Sawano Y, Kubota K, Kang HJ, Asano A, Miyauchi Y, Takahashi M, Zhi Y, Fujita Y, Yoshida T, Kodaira KS, Yamaguchi-Shinozaki K, Tanokura M (2009) Structural basis of abscisic acid signalling. Nature 462, 609–614[13]
Nishimura N, Hitomi K, Arvai AS, Rambo RP, Hitomi C, Cutler SR, Schroeder JI, Getzoff ED (2009) Structural mechanism of abscisic acid binding and signaling by dimeric PYR1. Science 326, 1373–1379[14]
Santiago J, Rodrigues A, Saez A, Rubio S, Antoni R, Dupeux F, Park SY, Marquez JA, Cutler SR, Rodriguez PL (2009b) Modulation of drought resistance by the abscisic acid receptor PYL5 through inhibition of clade A PP2Cs. Plant J. 60, 575–588[15]
YinP,FanH,HaoQ,YuanX,WuD,PangY,YanC,LiW,WangJ,Yan N (2009) Structural insights into the mechanism of abscisic acid signaling by PYL proteins. Nat. Struct. Mol. Biol. 16, 1230–1236[16]
Structural insights into PYR/PYL/RCAR ABA receptors and PP2Cs.
Santiago J, Dupeux F, Betz K, Antoni R, Gonzalez-Guzman M, Rodriguez L, Márquez JA, Rodriguez PL.Plant Sci. 2012 182:3-11[17]



ReferencesReferences

  1. ↑ Leung J, Giraudat J. ABSCISIC ACID SIGNAL TRANSDUCTION. Annu Rev Plant Physiol Plant Mol Biol. 1998 Jun;49:199-222. PMID:15012233 doi:10.1146/annurev.arplant.49.1.199
  2. ↑ Finkelstein RR, Gampala SS, Rock CD. Abscisic acid signaling in seeds and seedlings. Plant Cell. 2002;14 Suppl:S15-45. PMID:12045268
  3. ↑ Yin P, Fan H, Hao Q, Yuan X, Wu D, Pang Y, Yan C, Li W, Wang J, Yan N. Structural insights into the mechanism of abscisic acid signaling by PYL proteins. Nat Struct Mol Biol. 2009 Dec;16(12):1230-6. Epub 2009 Nov 5. PMID:19893533 doi:10.1038/nsmb.1730
  4. ↑ Ma Y, Szostkiewicz I, Korte A, Moes D, Yang Y, Christmann A, Grill E. Regulators of PP2C phosphatase activity function as abscisic acid sensors. Science. 2009 May 22;324(5930):1064-8. doi: 10.1126/science.1172408. Epub 2009, Apr 30. PMID:19407143 doi:10.1126/science.1172408
  5. ↑ Park SY, Fung P, Nishimura N, Jensen DR, Fujii H, Zhao Y, Lumba S, Santiago J, Rodrigues A, Chow TF, Alfred SE, Bonetta D, Finkelstein R, Provart NJ, Desveaux D, Rodriguez PL, McCourt P, Zhu JK, Schroeder JI, Volkman BF, Cutler SR. Abscisic acid inhibits type 2C protein phosphatases via the PYR/PYL family of START proteins. Science. 2009 May 22;324(5930):1068-71. doi: 10.1126/science.1173041. Epub 2009, Apr 30. PMID:19407142 doi:10.1126/science.1173041
  6. ↑ Geiger D, Scherzer S, Mumm P, Stange A, Marten I, Bauer H, Ache P, Matschi S, Liese A, Al-Rasheid KA, Romeis T, Hedrich R. Activity of guard cell anion channel SLAC1 is controlled by drought-stress signaling kinase-phosphatase pair. Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21425-30. doi:, 10.1073/pnas.0912021106. Epub 2009 Dec 2. PMID:19955405 doi:10.1073/pnas.0912021106
  7. ↑ Sato A, Sato Y, Fukao Y, Fujiwara M, Umezawa T, Shinozaki K, Hibi T, Taniguchi M, Miyake H, Goto DB, Uozumi N. Threonine at position 306 of the KAT1 potassium channel is essential for channel activity and is a target site for ABA-activated SnRK2/OST1/SnRK2.6 protein kinase. Biochem J. 2009 Dec 10;424(3):439-48. doi: 10.1042/BJ20091221. PMID:19785574 doi:10.1042/BJ20091221
  8. ↑ Nakashima K, Fujita Y, Kanamori N, Katagiri T, Umezawa T, Kidokoro S, Maruyama K, Yoshida T, Ishiyama K, Kobayashi M, Shinozaki K, Yamaguchi-Shinozaki K. Three Arabidopsis SnRK2 protein kinases, SRK2D/SnRK2.2, SRK2E/SnRK2.6/OST1 and SRK2I/SnRK2.3, involved in ABA signaling are essential for the control of seed development and dormancy. Plant Cell Physiol. 2009 Jul;50(7):1345-63. doi: 10.1093/pcp/pcp083. Epub 2009, Jun 18. PMID:19541597 doi:10.1093/pcp/pcp083
  9. ↑ Furihata T, Maruyama K, Fujita Y, Umezawa T, Yoshida R, Shinozaki K, Yamaguchi-Shinozaki K. Abscisic acid-dependent multisite phosphorylation regulates the activity of a transcription activator AREB1. Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1988-93. Epub 2006 Jan 30. PMID:16446457 doi:10.1073/pnas.0505667103
  10. ↑ Fujii H, Verslues PE, Zhu JK. Identification of two protein kinases required for abscisic acid regulation of seed germination, root growth, and gene expression in Arabidopsis. Plant Cell. 2007 Feb;19(2):485-94. Epub 2007 Feb 16. PMID:17307925 doi:tpc.106.048538
  11. ↑ Melcher K, Ng LM, Zhou XE, Soon FF, Xu Y, Suino-Powell KM, Park SY, Weiner JJ, Fujii H, Chinnusamy V, Kovach A, Li J, Wang Y, Li J, Peterson FC, Jensen DR, Yong EL, Volkman BF, Cutler SR, Zhu JK, Xu HE. A gate-latch-lock mechanism for hormone signalling by abscisic acid receptors. Nature. 2009 Dec 3;462(7273):602-8. PMID:19898420 doi:10.1038/nature08613
  12. ↑ Melcher K, Zhou XE, Xu HE. Thirsty plants and beyond: structural mechanisms of abscisic acid perception and signaling. Curr Opin Struct Biol. 2010 Dec;20(6):722-9. doi: 10.1016/j.sbi.2010.09.007. Epub, 2010 Oct 14. PMID:20951573 doi:10.1016/j.sbi.2010.09.007
  13. ↑ Miyazono K, Miyakawa T, Sawano Y, Kubota K, Kang HJ, Asano A, Miyauchi Y, Takahashi M, Zhi Y, Fujita Y, Yoshida T, Kodaira KS, Yamaguchi-Shinozaki K, Tanokura M. Structural basis of abscisic acid signalling. Nature. 2009 Dec 3;462(7273):609-14. PMID:19855379 doi:10.1038/nature08583
  14. ↑ Nishimura N, Hitomi K, Arvai AS, Rambo RP, Hitomi C, Cutler SR, Schroeder JI, Getzoff ED. Structural mechanism of abscisic acid binding and signaling by dimeric PYR1. Science. 2009 Dec 4;326(5958):1373-9. Epub 2009 Oct 22. PMID:19933100
  15. ↑ Santiago J, Rodrigues A, Saez A, Rubio S, Antoni R, Dupeux F, Park SY, Marquez JA, Cutler SR, Rodriguez PL. Modulation of drought resistance by the abscisic acid receptor PYL5 through inhibition of clade A PP2Cs. Plant J. 2009 Nov;60(4):575-88. doi: 10.1111/j.1365-313X.2009.03981.x. Epub 2009 , Jul 16. PMID:19624469 doi:10.1111/j.1365-313X.2009.03981.x
  16. ↑ Yin P, Fan H, Hao Q, Yuan X, Wu D, Pang Y, Yan C, Li W, Wang J, Yan N. Structural insights into the mechanism of abscisic acid signaling by PYL proteins. Nat Struct Mol Biol. 2009 Dec;16(12):1230-6. Epub 2009 Nov 5. PMID:19893533 doi:10.1038/nsmb.1730
  17. ↑ Santiago J, Dupeux F, Betz K, Antoni R, Gonzalez-Guzman M, Rodriguez L, Marquez JA, Rodriguez PL. Structural insights into PYR/PYL/RCAR ABA receptors and PP2Cs. Plant Sci. 2012 Jan;182:3-11. doi: 10.1016/j.plantsci.2010.11.014. Epub 2010 Dec , 7. PMID:22118610 doi:10.1016/j.plantsci.2010.11.014

See AlsoSee Also

[1] Abscisic Acid in Wikipedia

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