4c4m: Difference between revisions
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{{STRUCTURE_4c4m| PDB=4c4m | SCENE= }} | |||
===Crystal structure of the Sonic Hedgehog-chondroitin-4-sulphate complex=== | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/SHH_MOUSE SHH_MOUSE]] Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction (By similarity).<ref>PMID:7736596</ref> | |||
==About this Structure== | |||
[[4c4m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C4M OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Mus musculus]] | |||
[[Category: Gilbert, R J.C.]] | |||
[[Category: Malinauskas, T.]] | |||
[[Category: Siebold, C.]] | |||
[[Category: Whalen, D M.]] | |||
[[Category: Glycosaminoglycan]] | |||
[[Category: Hedgehog signalling]] | |||
[[Category: Heparan sulphate proteoglycan]] | |||
[[Category: Morphogen]] | |||
[[Category: Signaling protein]] | |||
Revision as of 10:32, 2 October 2013
Crystal structure of the Sonic Hedgehog-chondroitin-4-sulphate complexCrystal structure of the Sonic Hedgehog-chondroitin-4-sulphate complex
FunctionFunction
[SHH_MOUSE] Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction (By similarity).[1]
About this StructureAbout this Structure
4c4m is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.