4lix: Difference between revisions
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{{STRUCTURE_4lix| PDB=4lix | SCENE= }} | |||
===Crystal structure of ent-copalyl diphosphate synthase from Arabidopsis thaliana in complex with (S)-15-aza-14,15-dihydrogeranylgeranyl thiolodiphosphate at 1.55 A resolution=== | |||
{{ABSTRACT_PUBMED_24036329}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/KSA_ARATH KSA_ARATH]] Catalyzes the conversion of geranylgeranyl diphosphate to the gibberellin precursor ent-copalyl diphosphate.<ref>PMID:17457817</ref> <ref>PMID:20430888</ref> | |||
==About this Structure== | |||
[[4lix]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ochroconis_lascauxensis Ochroconis lascauxensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LIX OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024036329</ref><references group="xtra"/><references/> | |||
[[Category: Ent-copalyl diphosphate synthase]] | |||
[[Category: Ochroconis lascauxensis]] | |||
[[Category: Christianson, D W.]] | |||
[[Category: Koksal, M.]] | |||
[[Category: Biosynthesis of ent-copalyl diphosphate]] | |||
[[Category: Class i and ii terpene cyclase fold]] | |||
[[Category: Class ii diterpene cyclase]] | |||
[[Category: Dxdd motif]] | |||
[[Category: Gibberellin biosynthesis]] | |||
[[Category: Isomerase]] | |||
Revision as of 10:22, 2 October 2013
Crystal structure of ent-copalyl diphosphate synthase from Arabidopsis thaliana in complex with (S)-15-aza-14,15-dihydrogeranylgeranyl thiolodiphosphate at 1.55 A resolutionCrystal structure of ent-copalyl diphosphate synthase from Arabidopsis thaliana in complex with (S)-15-aza-14,15-dihydrogeranylgeranyl thiolodiphosphate at 1.55 A resolution
Template:ABSTRACT PUBMED 24036329
FunctionFunction
[KSA_ARATH] Catalyzes the conversion of geranylgeranyl diphosphate to the gibberellin precursor ent-copalyl diphosphate.[1] [2]
About this StructureAbout this Structure
4lix is a 1 chain structure with sequence from Ochroconis lascauxensis. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Koksal M, Potter K, Peters RJ, Christianson DW. 1.55A-resolution structure of ent-copalyl diphosphate synthase and exploration of general acid function by site-directed mutagenesis. Biochim Biophys Acta. 2013 Sep 12. pii: S0304-4165(13)00379-6. doi:, 10.1016/j.bbagen.2013.09.004. PMID:24036329 doi:10.1016/j.bbagen.2013.09.004
- ↑ Prisic S, Xu J, Coates RM, Peters RJ. Probing the role of the DXDD motif in Class II diterpene cyclases. Chembiochem. 2007 May 25;8(8):869-74. PMID:17457817 doi:10.1002/cbic.200700045
- ↑ Mann FM, Prisic S, Davenport EK, Determan MK, Coates RM, Peters RJ. A single residue switch for Mg(2+)-dependent inhibition characterizes plant class II diterpene cyclases from primary and secondary metabolism. J Biol Chem. 2010 Jul 2;285(27):20558-63. doi: 10.1074/jbc.M110.123307. Epub 2010, Apr 29. PMID:20430888 doi:10.1074/jbc.M110.123307