4m6q: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_4m6q| PDB=4m6q | SCENE= }} | |||
===Identification of Amides Derived From 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)=== | |||
{{ABSTRACT_PUBMED_24021463}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity). | |||
==About this Structure== | |||
[[4m6q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M6Q OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024021463</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Nicotinamide phosphoribosyltransferase]] | |||
[[Category: Bravo, B.]] | |||
[[Category: Brien, T O.]] | |||
[[Category: Dragovich, P S.]] | |||
[[Category: Feng, Y.]] | |||
[[Category: Giannetti, A M.]] | |||
[[Category: Gunzner-Toste, J.]] | |||
[[Category: Ho, Y.]] | |||
[[Category: Hua, R.]] | |||
[[Category: Liederer, B M.]] | |||
[[Category: Liu, Y.]] | |||
[[Category: Oeh, J.]] | |||
[[Category: Sampath, D.]] | |||
[[Category: Shen, Y.]] | |||
[[Category: Skelton, N.]] | |||
[[Category: Wang, C.]] | |||
[[Category: Wang, L.]] | |||
[[Category: Wang, W.]] | |||
[[Category: Wu, H.]] | |||
[[Category: Xiao, Y.]] | |||
[[Category: Yuen, P.]] | |||
[[Category: Zak, M.]] | |||
[[Category: Zhao, G.]] | |||
[[Category: Zhao, Q.]] | |||
[[Category: Zheng, X.]] | |||
[[Category: Transferase]] | |||
[[Category: Transferase-transferase inhibitor complex]] | |||
Revision as of 11:09, 29 September 2013
Identification of Amides Derived From 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)Identification of Amides Derived From 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)
Template:ABSTRACT PUBMED 24021463
FunctionFunction
[NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
About this StructureAbout this Structure
4m6q is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Zheng X, Bair KW, Bauer P, Baumeister T, Bowman KK, Buckmelter AJ, Caligiuri M, Clodfelter KH, Feng Y, Han B, Ho YC, Kley N, Li H, Liang X, Liederer BM, Lin J, Ly J, O'Brien T, Oeh J, Oh A, Reynolds DJ, Sampath D, Sharma G, Skelton N, Smith CC, Tremayne J, Wang L, Wang W, Wang Z, Wu H, Wu J, Xiao Y, Yang G, Yuen PW, Zak M, Dragovich PS. Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg Med Chem Lett. 2013 Oct 15;23(20):5488-97. doi:, 10.1016/j.bmcl.2013.08.074. Epub 2013 Aug 22. PMID:24021463 doi:10.1016/j.bmcl.2013.08.074
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCACategories:
- Homo sapiens
- Nicotinamide phosphoribosyltransferase
- Bravo, B.
- Brien, T O.
- Dragovich, P S.
- Feng, Y.
- Giannetti, A M.
- Gunzner-Toste, J.
- Ho, Y.
- Hua, R.
- Liederer, B M.
- Liu, Y.
- Oeh, J.
- Sampath, D.
- Shen, Y.
- Skelton, N.
- Wang, C.
- Wang, L.
- Wang, W.
- Wu, H.
- Xiao, Y.
- Yuen, P.
- Zak, M.
- Zhao, G.
- Zhao, Q.
- Zheng, X.
- Transferase
- Transferase-transferase inhibitor complex