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Calcium/Calmodulin-dependent protein kinase: Difference between revisions

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{{STRUCTURE_3mfr|  PDB=3mfr  | SIZE=400| SCENE=CaMKc/Cv/1 |right|CAPTION=Ca2+/Calmodulin dependent protein kinase complex with phosphoaminophosphonic acid-adenylate ester, [[3mfr]] }}
{{STRUCTURE_3mfr|  PDB=3mfr  | SIZE=400| SCENE=CaMKc/Cv/1 |right|CAPTION=Ca2+/Calmodulin dependent protein kinase complex with phosphoaminophosphonic acid-adenylate ester, [[3mfr]] }}


[[Ca2+/Calmodulin dependent protein kinase]] (CaMK) phosphorylates Ser and Thr.  It is regulated by Ca2+/[[Calmodulin]] (CaM).  It contains an N-terminal catalytic domain, regulatory domain (CBD) and association domain (ASD).  CaMKI is a specialized CaM kinase while CaMKII is multifunctional kinase.  '''CASK''' is a membrane associated CaMK. '''DAPK''' is a death-associated CaMK which protects cells from some programmed cell death.  It contains a regulatory (RD) and autoinhibitory (AD) domains. The images at the left and at the right correspond to one representative CaMK, ''i.e.'' crystal structure of human native membrane associated Ca2+/Calmodulin dependent protein kinase ([[3mfr]]).
[[Ca2+/Calmodulin dependent protein kinase]] (CaMK) phosphorylates Ser and Thr.  It is regulated by Ca<sup>2+</sup>/[[Calmodulin]] (CaM).  It contains an N-terminal catalytic domain, regulatory domain (CBD) and association domain (ASD).  CaMKI is a specialized CaM kinase while CaMKII is multifunctional kinase.  '''CASK''' is a membrane associated CaMK. '''DAPK''' is a death-associated CaMK which protects cells from some programmed cell death.  It contains a regulatory (RD) and autoinhibitory (AD) domains. The images at the left and at the right correspond to one representative CaMK, ''i.e.'' crystal structure of human native membrane associated Ca<sup>2+</sup>/Calmodulin dependent protein kinase ([[3mfr]]).


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== 3D Structures of Ca2+/Calmodulin dependent protein kinase ==
== 3D Structures of Ca<sup>2+</sup>/Calmodulin dependent protein kinase ==


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Alexander Berchansky, Michal Harel, Alice Harmon, Jaime Prilusky
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