2o39: Difference between revisions
New page: left|200px<br /> <applet load="2o39" size="450" color="white" frame="true" align="right" spinBox="true" caption="2o39, resolution 2.85Å" /> '''Human Adenovirus ty... |
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[[Image:2o39.gif|left|200px]]<br /> | [[Image:2o39.gif|left|200px]]<br /><applet load="2o39" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="2o39" size=" | |||
caption="2o39, resolution 2.85Å" /> | caption="2o39, resolution 2.85Å" /> | ||
'''Human Adenovirus type 11 knob in complex with domains SCR1 and SCR2 of CD46 (membrane cofactor protein, MCP)'''<br /> | '''Human Adenovirus type 11 knob in complex with domains SCR1 and SCR2 of CD46 (membrane cofactor protein, MCP)'''<br /> | ||
==Overview== | ==Overview== | ||
Adenoviruses (Ads) are important human pathogens and valuable gene | Adenoviruses (Ads) are important human pathogens and valuable gene delivery vehicles. We report here the crystal structure of the species B Ad11 knob complexed with the Ad11-binding region of its receptor CD46. The conformation of bound CD46 differs profoundly from its unbound state, with the bent surface structure straightened into an elongated rod. This mechanism of interaction is likely to be conserved among many pathogens that target CD46 or related molecules. | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
2O39 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_adenovirus_type_35p Human adenovirus type 35p] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 2O39 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_adenovirus_type_35p Human adenovirus type 35p] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O39 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Arnberg, N.]] | [[Category: Arnberg, N.]] | ||
[[Category: Persson, D | [[Category: Persson, D B.]] | ||
[[Category: Reiter, D | [[Category: Reiter, D M.]] | ||
[[Category: Stehle, T.]] | [[Category: Stehle, T.]] | ||
[[Category: CA]] | [[Category: CA]] | ||
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[[Category: virus receptor complex]] | [[Category: virus receptor complex]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:13:59 2008'' | ||
Revision as of 19:14, 21 February 2008
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Human Adenovirus type 11 knob in complex with domains SCR1 and SCR2 of CD46 (membrane cofactor protein, MCP)
OverviewOverview
Adenoviruses (Ads) are important human pathogens and valuable gene delivery vehicles. We report here the crystal structure of the species B Ad11 knob complexed with the Ad11-binding region of its receptor CD46. The conformation of bound CD46 differs profoundly from its unbound state, with the bent surface structure straightened into an elongated rod. This mechanism of interaction is likely to be conserved among many pathogens that target CD46 or related molecules.
DiseaseDisease
Known diseases associated with this structure: Hemolytic-uremic syndrome OMIM:[120920], Measles, susceptibility to OMIM:[120920]
About this StructureAbout this Structure
2O39 is a Protein complex structure of sequences from Homo sapiens and Human adenovirus type 35p with as ligand. Full crystallographic information is available from OCA.
ReferenceReference
Adenovirus type 11 binding alters the conformation of its receptor CD46., Persson BD, Reiter DM, Marttila M, Mei YF, Casasnovas JM, Arnberg N, Stehle T, Nat Struct Mol Biol. 2007 Feb;14(2):164-6. Epub 2007 Jan 14. PMID:17220899
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