4ll9: Difference between revisions
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{{STRUCTURE_4ll9| PDB=4ll9 | SCENE= }} | |||
===Crystal structure of D3D4 domain of the LILRB1 molecule=== | |||
{{ABSTRACT_PUBMED_23955630}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/LIRB1_HUMAN LIRB1_HUMAN]] Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.<ref>PMID:9285411</ref> <ref>PMID:9842885</ref> <ref>PMID:11907092</ref> | |||
==About this Structure== | |||
[[4ll9]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LL9 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023955630</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Gao, G F.]] | |||
[[Category: Liu, J.]] | |||
[[Category: Nam, G.]] | |||
[[Category: Qi, J.]] | |||
[[Category: Ryu, M.]] | |||
[[Category: Shi, Y.]] | |||
[[Category: Song, H.]] | |||
[[Category: Wang, Q.]] | |||
[[Category: Yan, J.]] | |||
[[Category: Ig-like domain]] | |||
[[Category: Immune system]] | |||
[[Category: Immune-modulatory molecule]] | |||
Revision as of 08:26, 12 September 2013
Crystal structure of D3D4 domain of the LILRB1 moleculeCrystal structure of D3D4 domain of the LILRB1 molecule
Template:ABSTRACT PUBMED 23955630
FunctionFunction
[LIRB1_HUMAN] Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.[1] [2] [3]
About this StructureAbout this Structure
4ll9 is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Nam G, Shi Y, Ryu M, Wang Q, Song H, Liu J, Yan J, Qi J, Gao GF. Crystal structures of the two membrane-proximal Ig-like domains (D3D4) of LILRB1/B2: alternative models for their involvement in peptide-HLA binding. Protein Cell. 2013 Aug 17. PMID:23955630 doi:10.1007/s13238-013-3908-x
- ↑ Cosman D, Fanger N, Borges L, Kubin M, Chin W, Peterson L, Hsu ML. A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules. Immunity. 1997 Aug;7(2):273-82. PMID:9285411
- ↑ Fanger NA, Cosman D, Peterson L, Braddy SC, Maliszewski CR, Borges L. The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes. Eur J Immunol. 1998 Nov;28(11):3423-34. PMID:9842885
- ↑ Bellon T, Kitzig F, Sayos J, Lopez-Botet M. Mutational analysis of immunoreceptor tyrosine-based inhibition motifs of the Ig-like transcript 2 (CD85j) leukocyte receptor. J Immunol. 2002 Apr 1;168(7):3351-9. PMID:11907092