4irs: Difference between revisions
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{{STRUCTURE_4irs| PDB=4irs | SCENE= }} | |||
===Structure of the mouse CD1d-PyrC-alpha-GalCer-iNKT TCR complex=== | |||
{{ABSTRACT_PUBMED_23960235}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CD1D1_MOUSE CD1D1_MOUSE]] Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.<ref>PMID:11754812</ref> <ref>PMID:16314439</ref> <ref>PMID:16007091</ref> [[http://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | |||
==About this Structure== | |||
[[4irs]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IRS OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023960235</ref><references group="xtra"/><references/> | |||
[[Category: Mus musculus]] | |||
[[Category: Nemcovic, M.]] | |||
[[Category: Zajonc, D M.]] | |||
[[Category: Antigen presentation]] | |||
[[Category: Glycolipid]] | |||
[[Category: Immune system]] | |||
[[Category: Nkt cell]] | |||
Revision as of 13:47, 4 September 2013
Structure of the mouse CD1d-PyrC-alpha-GalCer-iNKT TCR complexStructure of the mouse CD1d-PyrC-alpha-GalCer-iNKT TCR complex
Template:ABSTRACT PUBMED 23960235
FunctionFunction
[CD1D1_MOUSE] Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.[1] [2] [3] [B2MG_MOUSE] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
About this StructureAbout this Structure
4irs is a 4 chain structure with sequence from [1] and Mus musculus. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Aspeslagh S, Nemcovic M, Pauwels N, Venken K, Wang J, Van Calenbergh S, Zajonc DM, Elewaut D. Enhanced TCR Footprint by a Novel Glycolipid Increases NKT-Dependent Tumor Protection. J Immunol. 2013 Aug 19. PMID:23960235 doi:10.4049/jimmunol.1203134
- ↑ Jayawardena-Wolf J, Benlagha K, Chiu YH, Mehr R, Bendelac A. CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and by the invariant chain. Immunity. 2001 Dec;15(6):897-908. PMID:11754812
- ↑ Zajonc DM, Maricic I, Wu D, Halder R, Roy K, Wong CH, Kumar V, Wilson IA. Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity. J Exp Med. 2005 Dec 5;202(11):1517-26. Epub 2005 Nov 28. PMID:16314439 doi:10.1084/jem.20051625
- ↑ Zajonc DM, Cantu C 3rd, Mattner J, Zhou D, Savage PB, Bendelac A, Wilson IA, Teyton L. Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor. Nat Immunol. 2005 Aug;6(8):810-8. Epub 2005 Jul 10. PMID:16007091 doi:10.1038/ni1224