4ldd: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_4ldd| PDB=4ldd | SCENE= }} | {{STRUCTURE_4ldd| PDB=4ldd | SCENE= }} | ||
===Crystal Structure of Ebola virus VP40 Hexamer=== | ===Crystal Structure of Ebola virus VP40 Hexamer=== | ||
{{ABSTRACT_PUBMED_23953110}} | |||
==Function== | ==Function== | ||
| Line 9: | Line 10: | ||
==Reference== | ==Reference== | ||
<references group="xtra"/><references/> | <ref group="xtra">PMID:023953110</ref><references group="xtra"/><references/> | ||
[[Category: Zaire ebolavirus]] | [[Category: Zaire ebolavirus]] | ||
[[Category: Ableson, D M.]] | [[Category: Ableson, D M.]] | ||
Revision as of 11:42, 4 September 2013
Crystal Structure of Ebola virus VP40 HexamerCrystal Structure of Ebola virus VP40 Hexamer
Template:ABSTRACT PUBMED 23953110
FunctionFunction
[VP40_EBOZM] Promotes virus assembly and budding by interacting with host proteins of the multivesicular body pathway. May facilitate virus budding by interacting with the nucleocapsid and the plasma membrane. Specific interactions with membrane-associated GP and VP24 during the budding process may also occur. The hexamer form seems to be involved in budding. The octamer form binds RNA, and may play a role in genome replication.[1] [2]
About this StructureAbout this Structure
4ldd is a 3 chain structure with sequence from Zaire ebolavirus. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Bornholdt ZA, Noda T, Abelson DM, Halfmann P, Wood MR, Kawaoka Y, Saphire EO. Structural Rearrangement of Ebola Virus VP40 Begets Multiple Functions in the Virus Life Cycle. Cell. 2013 Aug 15;154(4):763-74. doi: 10.1016/j.cell.2013.07.015. PMID:23953110 doi:10.1016/j.cell.2013.07.015
- ↑ Irie T, Licata JM, Harty RN. Functional characterization of Ebola virus L-domains using VSV recombinants. Virology. 2005 Jun 5;336(2):291-8. PMID:15892969 doi:10.1016/j.virol.2005.03.027
- ↑ Johnson RF, Bell P, Harty RN. Effect of Ebola virus proteins GP, NP and VP35 on VP40 VLP morphology. Virol J. 2006 May 23;3:31. PMID:16719918 doi:10.1186/1743-422X-3-31