6-deoxyerythronolide B synthase (DEBS): Difference between revisions
No edit summary |
No edit summary |
||
| Line 31: | Line 31: | ||
=== Ketoreductase (KR) === | === Ketoreductase (KR) === | ||
The ketoreductase domain of a PKS is an optional tailoring domain that reduces a beta-ketoacyl ACP intermediate to the beta-hydroxy acyl ACP. NADPH, the co-factor for the KR domain, furnishes the hydride that is used in the reduction. | The ketoreductase domain of a PKS is an optional tailoring domain that reduces a beta-ketoacyl ACP intermediate to the beta-hydroxy acyl ACP. NADPH, the co-factor for the KR domain, furnishes the hydride that is used in the reduction. | ||
[[The Erythromycin KR domain]]<scene name='55/559997/Kr/1'> | [[The Erythromycin KR domain]]<scene name='55/559997/Kr/1'>KR domain</scene> | ||