Sandbox Mati: Difference between revisions
Mati Cohen (talk | contribs) No edit summary |
Mati Cohen (talk | contribs) No edit summary |
||
| Line 5: | Line 5: | ||
<scene name='43/437742/2yxj_glu/2'>two negativly charged residues</scene> Glu96 and Glu129. | <scene name='43/437742/2yxj_glu/2'>two negativly charged residues</scene> Glu96 and Glu129. | ||
Two <scene name='43/437742/2yxj_hydrophobic/1'>hydrophobic patches</scene> which include Phe191 Val141 and | Two <scene name='43/437742/2yxj_hydrophobic/1'>hydrophobic patches</scene> which include Phe191 Val141 and | ||
Ala93 for one, and the other patch includes Phe146 Val126 and Leu108. one can look at the <scene name='43/437742/2yxj_space_fill_color_charged/2'>Overall</scene> picture that there are hydropobic patches | Ala93 for one, and the other patch includes Phe146 Val126 and Leu108. one can look at the <scene name='43/437742/2yxj_space_fill_color_charged/2'>Overall</scene> picture that there are hydropobic patches (in gray) "above" and "below" the ligand ,negatively charged residues "above-right" and "below-left" of the ligand and positively charges on the "right" and "left" of it. | ||
This symmetry can be exploited, a symmetric molecule can bind the same interface in two different ways thus increasing the "chance" of binding which means better binding affinity. | This symmetry can be exploited, a symmetric molecule can bind the same interface in two different ways thus increasing the "chance" of binding which means better binding affinity. | ||