4m1j: Difference between revisions
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{{STRUCTURE_4m1j| PDB=4m1j | SCENE= }} | |||
===Crystal structure of Pseudomonas aeruginosa PvdQ in complex with a transition state analogue=== | |||
{{ABSTRACT_PUBMED_23883096}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PVDQ_PSEAE PVDQ_PSEAE]] Catalyzes the deacylation of acyl-homoserine lactone (AHL or acyl-HSL), releasing homoserine lactone (HSL) and the corresponding fatty acid. Possesses a specificity for the degradation of long-chain acyl-HSLs (side chains of 11 to 14 carbons in length). Degrades 3-oxo-C12-HSL, one of the two main AHL signal molecules of P.aeruginosa, and thereby functions as a quorum quencher, inhibiting the las quorum-sensing system. Therefore, may enable P.aeruginosa to modulate its own quorum-sensing-dependent pathogenic potential. Also appears to be required for pyoverdin biosynthesis.<ref>PMID:16495538</ref> <ref>PMID:14532048</ref> <ref>PMID:12686626</ref> | |||
==About this Structure== | |||
[[4m1j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M1J OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023883096</ref><references group="xtra"/><references/> | |||
[[Category: Acyl-homoserine-lactone acylase]] | |||
[[Category: Pseudomonas aeruginosa]] | |||
[[Category: Clevenger, K.]] | |||
[[Category: Er, J.]] | |||
[[Category: Fast, W L.]] | |||
[[Category: Liu, D.]] | |||
[[Category: Wu, R.]] | |||
[[Category: Acylase]] | |||
[[Category: Boronic acid]] | |||
[[Category: Heterodimer]] | |||
[[Category: Hydrolase]] | |||
[[Category: Secreted]] | |||
[[Category: Transition state analogue]] | |||