3vwi: Difference between revisions
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{{STRUCTURE_3vwi| PDB=3vwi | SCENE= }} | |||
===High resolution crystal structure of FraC in the monomeric form=== | |||
{{ABSTRACT_PUBMED_21300287}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ACTPC_ACTFR ACTPC_ACTFR]] Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes cardiac stimulation and hemolysis. Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of several monomers.<ref>PMID:19563820</ref> | |||
==About this Structure== | |||
[[3vwi]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Actinia_fragacea Actinia fragacea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VWI OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:021300287</ref><references group="xtra"/><references/> | |||
[[Category: Actinia fragacea]] | |||
[[Category: Caaveiro, J M.M.]] | |||
[[Category: Gonzalez-Manas, J M.]] | |||
[[Category: Morante, K.]] | |||
[[Category: Tanaka, K.]] | |||
[[Category: Tsumoto, K.]] | |||
[[Category: Actinoporin]] | |||
[[Category: Amphipathic alpha-helix]] | |||
[[Category: Beta-sandwich]] | |||
[[Category: Citolysin]] | |||
[[Category: Lipid raft]] | |||
[[Category: Membrane lipid]] | |||
[[Category: Pore-forming toxin]] | |||
[[Category: Secreted protein]] | |||
[[Category: Toxin]] | |||