3uxp: Difference between revisions
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{{STRUCTURE_3uxp| PDB=3uxp | SCENE= }} | {{STRUCTURE_3uxp| PDB=3uxp | SCENE= }} | ||
===Co-crystal Structure of Rat DNA polymerase beta Mutator I260Q: Enzyme-DNA-ddTTP=== | ===Co-crystal Structure of Rat DNA polymerase beta Mutator I260Q: Enzyme-DNA-ddTTP=== | ||
{{ABSTRACT_PUBMED_23651085}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/DPOLB_RAT DPOLB_RAT]] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. | |||
==About this Structure== | ==About this Structure== | ||
[[3uxp]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UXP OCA]. | [[3uxp]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UXP OCA]. | ||
==See Also== | |||
*[[DNA polymerase|DNA polymerase]] | |||
==Reference== | |||
<ref group="xtra">PMID:023651085</ref><references group="xtra"/><references/> | |||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Gridley, C L.]] | [[Category: Gridley, C L.]] | ||