User:Alice Harmon/Sandbox 2: Difference between revisions

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The crystal structure [[3ku2]] in the right scene shows <scene name='55/559103/Holo-ikinase/2'>inactive conformation</scene> the inactive conformation of the kinase that is bound only to the ANP (wireframe and CPK coloring). As above, the catalytic domain is blue and the CAD is gold. Note the large conformational change in the CAD (long alpha helices), and that it is bound to the same side of the kinase as the catalytic cleft, blocking it from binding peptide substrate.

The crystal structure [[3ku2]] in the right scene shows <scene name='55/559103/Holo-ikinase/4'>inactive conformation</scene> the inactive conformation of the kinase that is bound only to the ANP (wireframe and CPK coloring). As above, the catalytic domain is blue and the CAD is gold. Note the large conformational change in the CAD (long alpha helices), and that it is bound to the same side of the kinase as the catalytic cleft, blocking it from binding peptide substrate.

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 <Structure load='3HX4' size='500' frame='true' align='left' caption='3hx4 - active TgCDPK1' scene = '55/559103/Holo-akinase/2' />
-<Structure load='3HX4' size='500' frame='true' align='right' caption='3ku2 - inactive TgCDPK1' scene = '55/559103/Holo-ikinase/2' />
+<Structure load='3HX4' size='500' frame='true' align='right' caption='3ku2 - inactive TgCDPK1' scene = '55/559103/Holo-ikinase/4' />
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-The crystal structure [[3ku2]] in the right scene shows <scene name='55/559103/Holo-ikinase/2'>inactive conformation</scene> the inactive conformation of the kinase that is bound only to the ANP (wireframe and CPK coloring). As above, the catalytic domain is blue and the CAD is gold. Note the large conformational change in the CAD (long alpha helices), and that it is bound to the same side of the kinase as the catalytic cleft, blocking it from binding peptide substrate.
+The crystal structure [[3ku2]] in the right scene shows <scene name='55/559103/Holo-ikinase/4'>inactive conformation</scene> the inactive conformation of the kinase that is bound only to the ANP (wireframe and CPK coloring). As above, the catalytic domain is blue and the CAD is gold. Note the large conformational change in the CAD (long alpha helices), and that it is bound to the same side of the kinase as the catalytic cleft, blocking it from binding peptide substrate.