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CDPK
References
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==CDPK== | |||
Calcium-dependent protein kinases (CDPKs) are found in plants, algae, and apicomplexan protists, such as the parasites that cause malaria and toxoplasmosis. They are monomeric enzymes containing an amino-terminal protein kinase domain linked to a carboxy-terminal calcium-binding domain, that has sequence similarity to calmodulin. CDPKs belong to the calmodulin-dependent protein kinase family. | Calcium-dependent protein kinases (CDPKs) are found in plants, algae, and apicomplexan protists, such as the parasites that cause malaria and toxoplasmosis. They are monomeric enzymes containing an amino-terminal protein kinase domain linked to a carboxy-terminal calcium-binding domain, that has sequence similarity to calmodulin. CDPKs belong to the calmodulin-dependent protein kinase family. | ||
Crystal structures of inactive and active conformations of CDPK1 from ''Toxoplama gondii'' show the dramatic conformation change that occurs upon the binding of calcium to the regulatory domain <ref> PMID:20436473 </ref>. | Crystal structures of inactive and active conformations of CDPK1 from ''Toxoplama gondii'' show the dramatic conformation change that occurs upon the binding of calcium to the regulatory domain <ref> PMID:20436473 </ref>. | ||
<Structure load='3HX4' size='500' frame='true' align='right' caption='3hx4 - TgCDPK1 '55/559103/Holo-akinase/1' /> | |||
The crystal structure [[3hx4]] of the <scene name='55/559103/Holo-akinase/1'>active kinase</scene> shows | The crystal structure [[3hx4]] of the <scene name='55/559103/Holo-akinase/1'>active kinase</scene> shows | ||
==References== | |||
<references/> | |||
Revision as of 21:46, 22 August 2013
CDPKCDPK
Calcium-dependent protein kinases (CDPKs) are found in plants, algae, and apicomplexan protists, such as the parasites that cause malaria and toxoplasmosis. They are monomeric enzymes containing an amino-terminal protein kinase domain linked to a carboxy-terminal calcium-binding domain, that has sequence similarity to calmodulin. CDPKs belong to the calmodulin-dependent protein kinase family.
Crystal structures of inactive and active conformations of CDPK1 from Toxoplama gondii show the dramatic conformation change that occurs upon the binding of calcium to the regulatory domain [1].
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The crystal structure 3hx4 of the shows
ReferencesReferences
- ↑ Wernimont AK, Artz JD, Finerty P Jr, Lin YH, Amani M, Allali-Hassani A, Senisterra G, Vedadi M, Tempel W, Mackenzie F, Chau I, Lourido S, Sibley LD, Hui R. Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium. Nat Struct Mol Biol. 2010 May;17(5):596-601. Epub 2010 May 2. PMID:20436473 doi:10.1038/nsmb.1795