4bhx: Difference between revisions
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{{STRUCTURE_4bhx| PDB=4bhx | SCENE= }} | {{STRUCTURE_4bhx| PDB=4bhx | SCENE= }} | ||
===Crystal structure of the SCAN domain from human paternally expressed gene 3 protein=== | ===Crystal structure of the SCAN domain from human paternally expressed gene 3 protein=== | ||
{{ABSTRACT_PUBMED_23936039}} | |||
==Function== | ==Function== | ||
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==Reference== | ==Reference== | ||
<references group="xtra"/><references/> | <ref group="xtra">PMID:023936039</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Eadsforth, T C.]] | [[Category: Eadsforth, T C.]] | ||
Revision as of 11:26, 21 August 2013
Crystal structure of the SCAN domain from human paternally expressed gene 3 proteinCrystal structure of the SCAN domain from human paternally expressed gene 3 protein
Template:ABSTRACT PUBMED 23936039
FunctionFunction
[PEG3_HUMAN] Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells.[1]
About this StructureAbout this Structure
4bhx is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Rimsa V, Eadsforth TC, Hunter WN. Structure of the SCAN Domain of Human Paternally Expressed Gene 3 Protein. PLoS One. 2013 Jul 23;8(7):e69538. doi: 10.1371/journal.pone.0069538. Print 2013. PMID:23936039 doi:10.1371/journal.pone.0069538