User:Alice Harmon/Sandbox 1: Difference between revisions
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<scene name='55/555705/Subdomainiv/1'>Subdomain IV</scene> contains a beta strand and contributes to the core structure of the small lobe. | <scene name='55/555705/Subdomainiv/1'>Subdomain IV</scene> contains a beta strand and contributes to the core structure of the small lobe. | ||
<scene name='55/555705/Subdomainv/1'>Subdomain V</scene> links the small and large lobes. It contributes residues to the <scene name='55/555705/Atppocket/1'>binding pocket</scene> for the | <scene name='55/555705/Subdomainv/1'>Subdomain V</scene> links the small and large lobes. It contributes residues to the <scene name='55/555705/Atppocket/1'>ATP binding pocket</scene> and also for <scene name='55/555705/Glu127/1'>peptide substrate binding</scene>. In PKA Glu 127 (blue ball and stick) interacts with both the ribose of ATP and the first Arg (yellow ball and stick) in the phosphorylation motif RRxS of the peptide substrate. | ||
<scene name='55/555705/Subdomainvia/1'>Subdomain VIa</scene> contains the catalytic loop. | <scene name='55/555705/Subdomainvia/1'>Subdomain VIa</scene> contains the catalytic loop. | ||
Revision as of 21:54, 16 August 2013
Protein Kinase
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contains two beta strands connected by the glycine rich ATP-binding loop with the motif shown in ball and stick.
contains an that interacts with the phosphates of ATP.
connects to many parts of the kinase and its orientation is critical for activity. In the active conformation of the kinase the invariant in Subdomain III forms a salt bridge with the invariant lysine of Subdomain II (yellow ball and stick). This salt bridge couples subdomain III to ATP.
contains a beta strand and contributes to the core structure of the small lobe.
links the small and large lobes. It contributes residues to the and also for . In PKA Glu 127 (blue ball and stick) interacts with both the ribose of ATP and the first Arg (yellow ball and stick) in the phosphorylation motif RRxS of the peptide substrate.
contains the catalytic loop.
contains the Mg-binding loop with the DFG motif, the activation loop, the P+1 loop, and the APE motif.
contains the APE motif. The glutamate in this motif forms a salt bridge with an arginine in in Subdomain X1, which is critical for forming the stable kinase core.
and bind substrate proteins and forms the kinase core.