4lg5: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4lg5|  PDB=4lg5  |  SCENE=  }}
===ABA-mimicking ligand QUINABACTIN in complex with ABA receptor PYL2 and PP2C HAB1===
{{ABSTRACT_PUBMED_23835477}}


The entry 4lg5 is ON HOLD
==Function==
[[http://www.uniprot.org/uniprot/PYL2_ARATH PYL2_ARATH]] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.<ref>PMID:19898420</ref> <ref>PMID:19893533</ref>  [[http://www.uniprot.org/uniprot/P2C16_ARATH P2C16_ARATH]] Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth. Confers enhanced sensitivity to drought.<ref>PMID:14731256</ref> <ref>PMID:16876791</ref> <ref>PMID:16798945</ref> <ref>PMID:19033529</ref> 


Authors: Zhou, X.E., Gao, M., Liu, X., Zhang, Y., Xue, X., Melcher, K., Gao, P., Wang, F., Zeng, L., Zhao, Y., Zhao, Y., Deng, P., Zhong, D., Zhu, J.-K., Xu, Y., Xu, H.E.
==About this Structure==
[[4lg5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LG5 OCA].  


Description: ABA-mimicking ligand number 1 in complex with ABA receptor PYL2 and PP2C HAB1
==Reference==
<ref group="xtra">PMID:023835477</ref><references group="xtra"/><references/>
[[Category: Arabidopsis thaliana]]
[[Category: Phosphoprotein phosphatase]]
[[Category: Deng, P.]]
[[Category: Gao, M.]]
[[Category: Gao, P.]]
[[Category: Liu, X.]]
[[Category: Melcher, K.]]
[[Category: Wang, F.]]
[[Category: Xu, H E.]]
[[Category: Xu, Y.]]
[[Category: Xue, X.]]
[[Category: Zeng, L.]]
[[Category: Zhang, Y.]]
[[Category: Zhao, Y.]]
[[Category: Zhong, D.]]
[[Category: Zhou, X E.]]
[[Category: Zhu, J K.]]
[[Category: Abscisic acid mimicking compound]]
[[Category: Hydrolase-receptor-inhibitor complex]]
[[Category: Pp2c]]
[[Category: Pyr/pyl/rcar]]

Revision as of 10:48, 14 August 2013

Template:STRUCTURE 4lg5

ABA-mimicking ligand QUINABACTIN in complex with ABA receptor PYL2 and PP2C HAB1ABA-mimicking ligand QUINABACTIN in complex with ABA receptor PYL2 and PP2C HAB1

Template:ABSTRACT PUBMED 23835477

FunctionFunction

[PYL2_ARATH] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.[1] [2] [P2C16_ARATH] Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth. Confers enhanced sensitivity to drought.[3] [4] [5] [6]

About this StructureAbout this Structure

4lg5 is a 2 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA.

ReferenceReference

[xtra 1]

  1. ↑ Cao M, Liu X, Zhang Y, Xue X, Zhou XE, Melcher K, Gao P, Wang F, Zeng L, Zhao Y, Zhao Y, Deng P, Zhong D, Zhu JK, Xu HE, Xu Y. An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants. Cell Res. 2013 Aug;23(8):1043-54. doi: 10.1038/cr.2013.95. Epub 2013 Jul 9. PMID:23835477 doi:10.1038/cr.2013.95
  1. ↑ Melcher K, Ng LM, Zhou XE, Soon FF, Xu Y, Suino-Powell KM, Park SY, Weiner JJ, Fujii H, Chinnusamy V, Kovach A, Li J, Wang Y, Li J, Peterson FC, Jensen DR, Yong EL, Volkman BF, Cutler SR, Zhu JK, Xu HE. A gate-latch-lock mechanism for hormone signalling by abscisic acid receptors. Nature. 2009 Dec 3;462(7273):602-8. PMID:19898420 doi:10.1038/nature08613
  2. ↑ Yin P, Fan H, Hao Q, Yuan X, Wu D, Pang Y, Yan C, Li W, Wang J, Yan N. Structural insights into the mechanism of abscisic acid signaling by PYL proteins. Nat Struct Mol Biol. 2009 Dec;16(12):1230-6. Epub 2009 Nov 5. PMID:19893533 doi:10.1038/nsmb.1730
  3. ↑ Saez A, Apostolova N, Gonzalez-Guzman M, Gonzalez-Garcia MP, Nicolas C, Lorenzo O, Rodriguez PL. Gain-of-function and loss-of-function phenotypes of the protein phosphatase 2C HAB1 reveal its role as a negative regulator of abscisic acid signalling. Plant J. 2004 Feb;37(3):354-69. PMID:14731256
  4. ↑ Robert N, Merlot S, N'guyen V, Boisson-Dernier A, Schroeder JI. A hypermorphic mutation in the protein phosphatase 2C HAB1 strongly affects ABA signaling in Arabidopsis. FEBS Lett. 2006 Aug 21;580(19):4691-6. Epub 2006 Jul 24. PMID:16876791 doi:10.1016/j.febslet.2006.07.047
  5. ↑ Saez A, Robert N, Maktabi MH, Schroeder JI, Serrano R, Rodriguez PL. Enhancement of abscisic acid sensitivity and reduction of water consumption in Arabidopsis by combined inactivation of the protein phosphatases type 2C ABI1 and HAB1. Plant Physiol. 2006 Aug;141(4):1389-99. Epub 2006 Jun 23. PMID:16798945 doi:10.1104/pp.106.081018
  6. ↑ Saez A, Rodrigues A, Santiago J, Rubio S, Rodriguez PL. HAB1-SWI3B interaction reveals a link between abscisic acid signaling and putative SWI/SNF chromatin-remodeling complexes in Arabidopsis. Plant Cell. 2008 Nov;20(11):2972-88. doi: 10.1105/tpc.107.056705. Epub 2008 Nov, 25. PMID:19033529 doi:10.1105/tpc.107.056705

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