2jm6: Difference between revisions
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==Overview== | ==Overview== | ||
Apoptosis is held in check by prosurvival proteins of the Bcl-2 family. | Apoptosis is held in check by prosurvival proteins of the Bcl-2 family. The distantly related BH3-only proteins bind to and antagonize them, thereby promoting apoptosis. Whereas binding of the BH3-only protein Noxa to prosurvival Mcl-1 induces Mcl-1 degradation by the proteasome, binding of another BH3-only ligand, Bim, elevates Mcl-1 protein levels. We compared the three-dimensional structures of the complexes formed between BH3 peptides of both Bim and Noxa, and we show that a discrete C-terminal sequence of the Noxa BH3 is necessary to instigate Mcl-1 degradation. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Colman, P | [[Category: Colman, P M.]] | ||
[[Category: Czabotar, P | [[Category: Czabotar, P E.]] | ||
[[Category: Day, C | [[Category: Day, C L.]] | ||
[[Category: Delft, M | [[Category: Delft, M F.van.]] | ||
[[Category: Fairlie, W | [[Category: Fairlie, W D.]] | ||
[[Category: Hinds, M | [[Category: Hinds, M G.]] | ||
[[Category: Huang, D | [[Category: Huang, D C.S.]] | ||
[[Category: Lee, E | [[Category: Lee, E F.]] | ||
[[Category: Smith, B | [[Category: Smith, B J.]] | ||
[[Category: apoptosis]] | [[Category: apoptosis]] | ||
[[Category: bcl-2]] | [[Category: bcl-2]] | ||
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[[Category: mcl-1]] | [[Category: mcl-1]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:03:58 2008'' | ||
Revision as of 19:03, 21 February 2008
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Solution structure of MCL-1 complexed with NOXAB
OverviewOverview
Apoptosis is held in check by prosurvival proteins of the Bcl-2 family. The distantly related BH3-only proteins bind to and antagonize them, thereby promoting apoptosis. Whereas binding of the BH3-only protein Noxa to prosurvival Mcl-1 induces Mcl-1 degradation by the proteasome, binding of another BH3-only ligand, Bim, elevates Mcl-1 protein levels. We compared the three-dimensional structures of the complexes formed between BH3 peptides of both Bim and Noxa, and we show that a discrete C-terminal sequence of the Noxa BH3 is necessary to instigate Mcl-1 degradation.
About this StructureAbout this Structure
2JM6 is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.
ReferenceReference
Structural insights into the degradation of Mcl-1 induced by BH3 domains., Czabotar PE, Lee EF, van Delft MF, Day CL, Smith BJ, Huang DC, Fairlie WD, Hinds MG, Colman PM, Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6217-22. Epub 2007 Mar 27. PMID:17389404
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