Toll-like Receptors: Difference between revisions

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Wayne Decatur, David Canner, Michal Harel, Joel L. Sussman, Alexander Berchansky

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	Toll-like receptors, often abbreviated TLRs, are found on the surface of phagocytic cells of vertebrates and invertebrates and are critical to the innate immune system. The Toll-like receptors recognize molecular patterns associated with pathogens, such as double-stranded RNA, lipopolysaccharide, or CpG DNA, and initiate an intracellular kinase cascade, inducing an immediate defensive response.<ref>PMID: 20084417</ref><ref>PMID: 18064347</ref> The receptors are multi-domain structures consisting of an extracellular ectodomain, a transmembrane domain and a intracellular Toll/IL-1 receptor domain. The extracellular domains contain [[leucine-rich repeats]].		'''Toll-like receptors''', often abbreviated TLRs, are found on the surface of phagocytic cells of vertebrates and invertebrates and are critical to the innate immune system. The Toll-like receptors recognize molecular patterns associated with pathogens, such as double-stranded RNA, lipopolysaccharide, or CpG DNA, and initiate an intracellular kinase cascade, inducing an immediate defensive response.<ref>PMID: 20084417</ref><ref>PMID: 18064347</ref> The receptors are multi-domain structures consisting of an extracellular ectodomain, a transmembrane domain and a intracellular Toll/IL-1 receptor domain. The extracellular domains contain [[leucine-rich repeats]].