4lr6: Difference between revisions
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{{STRUCTURE_4lr6| PDB=4lr6 | SCENE= }} | |||
===Structure of BRD4 bromodomain 1 with a 3-methyl-4-phenylisoxazol-5-amine fragment=== | |||
==Disease== | |||
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | |||
==About this Structure== | |||
[[4lr6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LR6 OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Albrecht, B.]] | |||
[[Category: Audia, J.]] | |||
[[Category: Bellon, S.]] | |||
[[Category: Bergeron, L.]] | |||
[[Category: Birudukota, S.]] | |||
[[Category: Bryant, B.]] | |||
[[Category: Cote, A.]] | |||
[[Category: Gehling, V.]] | |||
[[Category: Harmange, J C.]] | |||
[[Category: Hewitt, M.]] | |||
[[Category: Jayaram, H.]] | |||
[[Category: Joshi, S.]] | |||
[[Category: Leblanc, Y.]] | |||
[[Category: Mertz, J.]] | |||
[[Category: Nandana, B S.]] | |||
[[Category: Nasveschuk, C.]] | |||
[[Category: Pardo, E.]] | |||
[[Category: Poy, F.]] | |||
[[Category: Sandy, P.]] | |||
[[Category: Sankaranarayanan, R.]] | |||
[[Category: Sims, R.]] | |||
[[Category: Taylor, A.]] | |||
[[Category: Vaswani, R.]] | |||
[[Category: Yellapuntala, S.]] | |||
[[Category: Bet inhibitor]] | |||
[[Category: Brd4 first bromodomain]] | |||
[[Category: Transcription regulator-inhibitor complex]] |