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' | {{STRUCTURE_4jsl| PDB=4jsl | SCENE= }} | ||
===Structure of bovine endothelial nitric oxide synthase heme domain in complex with 6,6'-(heptane-1,7-diyl)bis(4-methylpyridin-2-amine)=== | |||
{{ABSTRACT_PUBMED_23867386}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/NOS3_BOVIN NOS3_BOVIN]] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. | |||
==About this Structure== | |||
[[4jsl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JSL OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023867386</ref><references group="xtra"/><references/> | |||
[[Category: Bos taurus]] | |||
[[Category: Li, H.]] | |||
[[Category: Poulos, T L.]] | |||
[[Category: Nitric oxide synthase]] | |||
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]] | |||
Revision as of 23:54, 7 August 2013
Structure of bovine endothelial nitric oxide synthase heme domain in complex with 6,6'-(heptane-1,7-diyl)bis(4-methylpyridin-2-amine)Structure of bovine endothelial nitric oxide synthase heme domain in complex with 6,6'-(heptane-1,7-diyl)bis(4-methylpyridin-2-amine)
Template:ABSTRACT PUBMED 23867386
FunctionFunction
[NOS3_BOVIN] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
About this StructureAbout this Structure
4jsl is a 2 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Jing Q, Li H, Fang J, Roman LJ, Martasek P, Poulos TL, Silverman RB. In search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structures. Bioorg Med Chem. 2013 Jun 15. pii: S0968-0896(13)00545-2. doi:, 10.1016/j.bmc.2013.06.014. PMID:23867386 doi:10.1016/j.bmc.2013.06.014