4etp: Difference between revisions
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{{STRUCTURE_4etp| PDB=4etp | SCENE= }} | {{STRUCTURE_4etp| PDB=4etp | SCENE= }} | ||
===C-terminal motor and motor homology domain of Kar3Vik1 fused to a synthetic heterodimeric coiled coil=== | ===C-terminal motor and motor homology domain of Kar3Vik1 fused to a synthetic heterodimeric coiled coil=== | ||
{{ABSTRACT_PUBMED_22734002}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/KAR3_YEAST KAR3_YEAST]] Essential for yeast nuclear fusion during mating. KAR3 is a bifunctional protein having a kinesin-like motor domain joined to a distinct microtubule binding domain. It may mediate microtubule sliding during nuclear fusion and possibly mitosis. May interact with spindle microtubules to produce an inwardly directed force acting upon the poles. KAR3 function antagonizes CIP8 and KIP1 outward force action. KAR3 motor activity is directed toward the microtubule's minus end.<ref>PMID:2138512</ref> <ref>PMID:11729143</ref> [[http://www.uniprot.org/uniprot/VIK1_YEAST VIK1_YEAST]] Targets and/or maintains KAR3 at the spindle pole body during vegetative growth.<ref>PMID:10087265</ref> <ref>PMID:11729143</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[4etp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[4etp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ETP OCA]. | ||
[[Category: Saccharomyces cerevisiae]] | |||
==Reference== | |||
<ref group="xtra">PMID:022734002</ref><references group="xtra"/><references/> | |||
[[Category: Saccharomyces cerevisiae s288c]] | |||
[[Category: Chen, C J.]] | [[Category: Chen, C J.]] | ||
[[Category: Cope, J.]] | [[Category: Cope, J.]] | ||
Revision as of 22:08, 7 August 2013
C-terminal motor and motor homology domain of Kar3Vik1 fused to a synthetic heterodimeric coiled coilC-terminal motor and motor homology domain of Kar3Vik1 fused to a synthetic heterodimeric coiled coil
Template:ABSTRACT PUBMED 22734002
FunctionFunction
[KAR3_YEAST] Essential for yeast nuclear fusion during mating. KAR3 is a bifunctional protein having a kinesin-like motor domain joined to a distinct microtubule binding domain. It may mediate microtubule sliding during nuclear fusion and possibly mitosis. May interact with spindle microtubules to produce an inwardly directed force acting upon the poles. KAR3 function antagonizes CIP8 and KIP1 outward force action. KAR3 motor activity is directed toward the microtubule's minus end.[1] [2] [VIK1_YEAST] Targets and/or maintains KAR3 at the spindle pole body during vegetative growth.[3] [4]
About this StructureAbout this Structure
4etp is a 2 chain structure with sequence from Saccharomyces cerevisiae s288c. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Rank KC, Chen CJ, Cope J, Porche K, Hoenger A, Gilbert SP, Rayment I. Kar3Vik1, a member of the kinesin-14 superfamily, shows a novel kinesin microtubule binding pattern. J Cell Biol. 2012 Jun 25;197(7):957-70. doi: 10.1083/jcb.201201132. PMID:22734002 doi:10.1083/jcb.201201132
- ↑ Meluh PB, Rose MD. KAR3, a kinesin-related gene required for yeast nuclear fusion. Cell. 1990 Mar 23;60(6):1029-41. PMID:2138512
- ↑ Shanks RM, Kamieniecki RJ, Dawson DS. The Kar3-interacting protein Cik1p plays a critical role in passage through meiosis I in Saccharomyces cerevisiae. Genetics. 2001 Nov;159(3):939-51. PMID:11729143
- ↑ Manning BD, Barrett JG, Wallace JA, Granok H, Snyder M. Differential regulation of the Kar3p kinesin-related protein by two associated proteins, Cik1p and Vik1p. J Cell Biol. 1999 Mar 22;144(6):1219-33. PMID:10087265
- ↑ Shanks RM, Kamieniecki RJ, Dawson DS. The Kar3-interacting protein Cik1p plays a critical role in passage through meiosis I in Saccharomyces cerevisiae. Genetics. 2001 Nov;159(3):939-51. PMID:11729143