4jck: Difference between revisions
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{{STRUCTURE_4jck| PDB=4jck | SCENE= }} | |||
===Galectin-3 carbohydrate recognition domain in complex with thioditaloside=== | |||
{{ABSTRACT_PUBMED_23864426}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN]] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref> | |||
==About this Structure== | |||
[[4jck]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JCK OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023864426</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Blanchard, H.]] | |||
[[Category: Bum-Erdene, K.]] | |||
[[Category: Beta sandwich]] | |||
[[Category: Carbohydrate binding protein]] | |||
[[Category: Sugar binding protein-inhibitor complex]] |