4bsk: Difference between revisions
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{{STRUCTURE_4bsk| PDB=4bsk | SCENE= }} | |||
===Crystal structure of VEGF-C in complex with VEGFR-3 domains D1-2=== | |||
{{ABSTRACT_PUBMED_23878260}} | |||
The entry | ==Disease== | ||
[[http://www.uniprot.org/uniprot/VGFR3_HUMAN VGFR3_HUMAN]] Milroy disease. The disease is caused by mutations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. Plays an important role in tumor lymphangiogenesis, in cancer cell survival, migration, and formation of metastases. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/VGFR3_HUMAN VGFR3_HUMAN]] Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'.<ref>PMID:8700872</ref> <ref>PMID:7675451</ref> <ref>PMID:9435229</ref> <ref>PMID:11532940</ref> <ref>PMID:15474514</ref> <ref>PMID:15102829</ref> <ref>PMID:16076871</ref> <ref>PMID:16452200</ref> <ref>PMID:17210781</ref> <ref>PMID:19779139</ref> <ref>PMID:19610651</ref> <ref>PMID:20431062</ref> <ref>PMID:20224550</ref> <ref>PMID:20445537</ref> <ref>PMID:21273538</ref> [[http://www.uniprot.org/uniprot/VEGFC_HUMAN VEGFC_HUMAN]] Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.<ref>PMID:20145116</ref> | |||
==About this Structure== | |||
[[4bsk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BSK OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023878260</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Receptor protein-tyrosine kinase]] | |||
[[Category: Alitalo, K.]] | |||
[[Category: Anisimov, A.]] | |||
[[Category: Ballmer-Hofer, K.]] | |||
[[Category: Goldie, K N.]] | |||
[[Category: Jeltsch, M.]] | |||
[[Category: Kisko, K.]] | |||
[[Category: Leppanen, V M.]] | |||
[[Category: Markovic-Mueller, S.]] | |||
[[Category: Prota, A E.]] | |||
[[Category: Stuttfeld, E.]] | |||
[[Category: Tvorogov, D.]] | |||
[[Category: Angiogenesis]] | |||
[[Category: Dimerization]] | |||
[[Category: Glycoprotein]] | |||
[[Category: Ig domain]] | |||
[[Category: Lymphangiogenesis]] | |||
[[Category: Receptor tyrosine kinase]] | |||
[[Category: Transferase]] | |||
[[Category: Transferase-hormone complex]] | |||