4bom: Difference between revisions
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{{STRUCTURE_4bom| PDB=4bom | SCENE= }} | |||
===Structure of herpesvirus fusion glycoprotein B-bilayer complex revealing the protein-membrane and lateral protein-protein interaction=== | |||
{{ABSTRACT_PUBMED_23850455}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/GB_HHV1K GB_HHV1K]] Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moities of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding of gD to one of its receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress. Also plays a role, together with gK, in virus-induced cell-to-cell fusion (syncytia formation).<ref>PMID:17299053</ref> | |||
==About this Structure== | |||
[[4bom]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_1 Human herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BOM OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023850455</ref><references group="xtra"/><references/> | |||
[[Category: Human herpesvirus 1]] | |||
[[Category: Cairns, T M.]] | |||
[[Category: Cohen, G H.]] | |||
[[Category: Eisenberg, R J.]] | |||
[[Category: Grunewald, K.]] | |||
[[Category: Hannah, B P.]] | |||
[[Category: Huiskonen, J T.]] | |||
[[Category: Maurer, U E.]] | |||
[[Category: Pandurangan, A P.]] | |||
[[Category: Topf, M.]] | |||
[[Category: Whitbeck, J C.]] | |||
[[Category: Zeev-Ben-Mordehai, Z.]] | |||
[[Category: Membrane proximal region]] | |||
[[Category: Protein coat]] | |||
[[Category: Pseudo-atomic virus-host interaction]] | |||
[[Category: Viral protein]] |