4b1x: Difference between revisions
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{{STRUCTURE_4b1x| PDB=4b1x | SCENE= }} | |||
===Structure of the Phactr1 RPEL-2 bound to G-actin=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ACTS_RABIT ACTS_RABIT]] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. [[http://www.uniprot.org/uniprot/PHAR1_MOUSE PHAR1_MOUSE]] Binds actin monomers (G actin) and plays a role in the reorganization of the actin cytoskeleton and in formation of actin stress fibers. Plays a role in the formation of tubules by endothelial cells. Regulates PPP1CA activity. Required for normal cell survival (By similarity). Plays a role in cell motility.<ref>PMID:22976292</ref> <ref>PMID:23041370</ref> | |||
==About this Structure== | |||
[[4b1x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B1X OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Oryctolagus cuniculus]] | |||
[[Category: McDonald, N Q.]] | |||
[[Category: Mouilleron, S.]] | |||
[[Category: Reilly, N O.]] | |||
[[Category: Treisman, R.]] | |||
[[Category: Wiezlak, M.]] | |||
[[Category: Atp-binding]] | |||
[[Category: Cytoskeleton]] | |||
[[Category: Muscle protein]] | |||
[[Category: Nucleotide-binding]] | |||
[[Category: Structural protein]] | |||
[[Category: Transcription]] | |||
[[Category: Transcription regulation]] | |||
Revision as of 08:12, 1 August 2013
Structure of the Phactr1 RPEL-2 bound to G-actinStructure of the Phactr1 RPEL-2 bound to G-actin
FunctionFunction
[ACTS_RABIT] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. [PHAR1_MOUSE] Binds actin monomers (G actin) and plays a role in the reorganization of the actin cytoskeleton and in formation of actin stress fibers. Plays a role in the formation of tubules by endothelial cells. Regulates PPP1CA activity. Required for normal cell survival (By similarity). Plays a role in cell motility.[1] [2]
About this StructureAbout this Structure
4b1x is a 2 chain structure with sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Wiezlak M, Diring J, Abella J, Mouilleron S, Way M, McDonald NQ, Treisman R. G-actin regulates the shuttling and PP1 binding of the RPEL protein Phactr1 to control actomyosin assembly. J Cell Sci. 2012 Dec 1;125(Pt 23):5860-72. doi: 10.1242/jcs.112078. Epub 2012 Sep, 12. PMID:22976292 doi:10.1242/jcs.112078
- ↑ Mouilleron S, Wiezlak M, O'Reilly N, Treisman R, McDonald NQ. Structures of the Phactr1 RPEL Domain and RPEL Motif Complexes with G-Actin Reveal the Molecular Basis for Actin Binding Cooperativity. Structure. 2012 Oct 2. pii: S0969-2126(12)00335-8. doi:, 10.1016/j.str.2012.08.031. PMID:23041370 doi:10.1016/j.str.2012.08.031