4lrh: Difference between revisions
New page: {{STRUCTURE_4lrh| PDB=4lrh | SCENE= }} ===Crystal structure of human folate receptor alpha in complex with folic acid=== {{ABSTRACT_PUBMED_23851396}} ==Disease== [[http://www.uniprot... |
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Revision as of 07:56, 1 August 2013
Crystal structure of human folate receptor alpha in complex with folic acidCrystal structure of human folate receptor alpha in complex with folic acid
Template:ABSTRACT PUBMED 23851396
DiseaseDisease
[FOLR1_HUMAN] Neurodegenerative syndrome due to cerebral folate transport deficiency. Neurodegeneration due to cerebral folate transport deficiency (NCFTD) [MIM:613068]: A neurodegenerative disorder resulting from brain-specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy and leukodystrophy. Note=The disease is caused by mutations affecting the gene represented in this entry.
FunctionFunction
[FOLR1_HUMAN] Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.
About this StructureAbout this Structure
4lrh is a 8 chain structure with sequence from Homo sapiens. This structure supersedes the now removed PDB entry 4keo. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Chen C, Ke J, Zhou XE, Yi W, Brunzelle JS, Li J, Yong EL, Xu HE, Melcher K. Structural basis for molecular recognition of folic acid by folate receptors. Nature. 2013 Jul 14. doi: 10.1038/nature12327. PMID:23851396 doi:10.1038/nature12327