2j4i: Difference between revisions
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==Overview== | ==Overview== | ||
Structure-based drug design was exploited in the synthesis of | Structure-based drug design was exploited in the synthesis of 3-(6-chloronaphth-2-ylsulfonyl)aminopyrrolidin-2-one-based factor Xa (fXa) inhibitors, incorporating an alanylamide P4 group with acyclic tertiary amide termini. Optimized hydrophobic contacts of one amide substituent in P4 were complemented by hydrophobicity-modulating features in the second, producing potent fXa inhibitors including examples with excellent anticoagulant properties. | ||
==Disease== | ==Disease== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Borthwick, A | [[Category: Borthwick, A D.]] | ||
[[Category: Brown, D.]] | [[Category: Brown, D.]] | ||
[[Category: Campbell, M.]] | [[Category: Campbell, M.]] | ||
[[Category: Chan, C.]] | [[Category: Chan, C.]] | ||
[[Category: Convery, M | [[Category: Convery, M A.]] | ||
[[Category: Crowe, M | [[Category: Crowe, M C.]] | ||
[[Category: Dayal, S.]] | [[Category: Dayal, S.]] | ||
[[Category: Diallo, H.]] | [[Category: Diallo, H.]] | ||
[[Category: Kelly, H | [[Category: Kelly, H A.]] | ||
[[Category: King, N | [[Category: King, N Paul.]] | ||
[[Category: Kleanthous, S.]] | [[Category: Kleanthous, S.]] | ||
[[Category: Kurtis, C | [[Category: Kurtis, C L.]] | ||
[[Category: Mason, A | [[Category: Mason, A M.]] | ||
[[Category: Mordaunt, J | [[Category: Mordaunt, J E.]] | ||
[[Category: Patel, C.]] | [[Category: Patel, C.]] | ||
[[Category: Pateman, A | [[Category: Pateman, A J.]] | ||
[[Category: Senger, S.]] | [[Category: Senger, S.]] | ||
[[Category: Shah, G | [[Category: Shah, G P.]] | ||
[[Category: Smith, P | [[Category: Smith, P W.]] | ||
[[Category: Watson, N | [[Category: Watson, N S.]] | ||
[[Category: Weston, H | [[Category: Weston, H E.]] | ||
[[Category: Young, R | [[Category: Young, R J.]] | ||
[[Category: Zhou, P.]] | [[Category: Zhou, P.]] | ||
[[Category: CA]] | [[Category: CA]] | ||
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[[Category: zymogen]] | [[Category: zymogen]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:59:05 2008'' | ||