2j47: Difference between revisions
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==Overview== | ==Overview== | ||
Synthesis of a PUGNAc-imidazole hybrid and its characterization as an | Synthesis of a PUGNAc-imidazole hybrid and its characterization as an inhibitor of human O-GlcNAcase through enzyme kinetics and X-ray structural analysis. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Beta-N-acetylhexosaminidase]] | [[Category: Beta-N-acetylhexosaminidase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Davies, G | [[Category: Davies, G J.]] | ||
[[Category: Dennis, R | [[Category: Dennis, R J.]] | ||
[[Category: GDV]] | [[Category: GDV]] | ||
[[Category: GOL]] | [[Category: GOL]] | ||
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[[Category: pugnac]] | [[Category: pugnac]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:59:01 2008'' | ||
Revision as of 18:59, 21 February 2008
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BACTEROIDES THETAIOTAOMICRON GH84 O-GLCNACASE IN COMPLEX WITH A IMIDAZOLE-PUGNAC HYBRID INHIBITOR
OverviewOverview
Synthesis of a PUGNAc-imidazole hybrid and its characterization as an inhibitor of human O-GlcNAcase through enzyme kinetics and X-ray structural analysis.
About this StructureAbout this Structure
2J47 is a Single protein structure of sequence from Bacteroides thetaiotaomicron with and as ligands. Active as Beta-N-acetylhexosaminidase, with EC number 3.2.1.52 Known structural/functional Site: . Full crystallographic information is available from OCA.
ReferenceReference
Inhibition of O-GlcNAcase by a gluco-configured nagstatin and a PUGNAc-imidazole hybrid inhibitor., Shanmugasundaram B, Debowski AW, Dennis RJ, Davies GJ, Vocadlo DJ, Vasella A, Chem Commun (Camb). 2006 Nov 13;(42):4372-4. Epub 2006 Sep 29. PMID:17057847
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