Sandbox 124: Difference between revisions
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pentaglycine chains. Peptidoglycan consists of N-acetylmuramic Acid (NAM) and | pentaglycine chains. Peptidoglycan consists of N-acetylmuramic Acid (NAM) and | ||
N-acetylglucosamine (NAG) polymers. The NAM residues have a five amino acid side | N-acetylglucosamine (NAG) polymers. The NAM residues have a five amino acid side | ||
chain that terminates with two D-Alanine (D-Ala) residues.''' | chain that terminates with two D-Alanine (D-Ala) residues. MRSA is resistant to all | ||
β-lactams because it acquires an alternative PBP, PBP2a, that is not bound or | |||
inhibited by any β-lactams. Recently, two cephalosporins - ceftobiprole and | |||
ceftaroline - that bind and inhibit PBP2a have been developed.''' | |||