4jph: Difference between revisions
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{{STRUCTURE_4jph| PDB=4jph | SCENE= }} | |||
===Crystal structure of Protein Related to DAN and Cerberus (PRDC)=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/GREM2_MOUSE GREM2_MOUSE]] Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner. Antagonized BMP4-induced suppression of progesterone production in granulosa cells.<ref>PMID:15039429</ref> | |||
==About this Structure== | |||
[[4jph]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JPH OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Mus musculus]] | |||
[[Category: Deng, X.]] | |||
[[Category: Kattamuri, C.]] | |||
[[Category: Nolan, K T.]] | |||
[[Category: Thompson, T B.]] | |||
[[Category: Bmp antagonist]] | |||
[[Category: Bmp-2]] | |||
[[Category: Bmp-4]] | |||
[[Category: Bmp-7]] | |||
[[Category: Can domain]] | |||
[[Category: Cystine knot]] | |||
[[Category: Cytokine]] | |||
[[Category: Dan domain]] | |||
[[Category: Extracellular]] | |||
[[Category: Gdf-5]] | |||
[[Category: Gsh]] | |||
Revision as of 16:12, 24 July 2013
Crystal structure of Protein Related to DAN and Cerberus (PRDC)Crystal structure of Protein Related to DAN and Cerberus (PRDC)
FunctionFunction
[GREM2_MOUSE] Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner. Antagonized BMP4-induced suppression of progesterone production in granulosa cells.[1]
About this StructureAbout this Structure
4jph is a 4 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Sudo S, Avsian-Kretchmer O, Wang LS, Hsueh AJ. Protein related to DAN and cerberus is a bone morphogenetic protein antagonist that participates in ovarian paracrine regulation. J Biol Chem. 2004 May 28;279(22):23134-41. Epub 2004 Mar 23. PMID:15039429 doi:10.1074/jbc.M402376200