2iui: Difference between revisions
New page: left|200px<br /> <applet load="2iui" size="450" color="white" frame="true" align="right" spinBox="true" caption="2iui, resolution 2.40Å" /> '''CRYSTAL STRUCTURE O... |
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[[Image:2iui.gif|left|200px]]<br /> | [[Image:2iui.gif|left|200px]]<br /><applet load="2iui" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="2iui" size=" | |||
caption="2iui, resolution 2.40Å" /> | caption="2iui, resolution 2.40Å" /> | ||
'''CRYSTAL STRUCTURE OF THE PI3-KINASE P85 N-TERMINAL SH2 DOMAIN IN COMPLEX WITH PDGFR PHOSPHOTYROSYL PEPTIDE'''<br /> | '''CRYSTAL STRUCTURE OF THE PI3-KINASE P85 N-TERMINAL SH2 DOMAIN IN COMPLEX WITH PDGFR PHOSPHOTYROSYL PEPTIDE'''<br /> | ||
==Overview== | ==Overview== | ||
Crystal structures of the amino-terminal SH2 domain of the p85alpha | Crystal structures of the amino-terminal SH2 domain of the p85alpha subunit of phosphatidylinositol (PI) 3-kinase, alone and in complex with phosphopeptides bearing pTyr-Met/Val-Xaa-Met motifs, show that phosphopeptides bind in the two-pronged manner seen in high-affinity Lck and Src SH2 complexes, with conserved interactions between the domain and the peptide segment from phosphotyrosine to Met+3. Peptide binding requires the rearrangement of a tyrosyl side chain in the BG loop to create the hydrophobic Met+3 binding pocket. The structures suggest a mechanism for the biological specificity exhibited by PI 3-kinase in its interactions with phosphoprotein partners. | ||
==About this Structure== | ==About this Structure== | ||
2IUI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | 2IUI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IUI OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Eck, M | [[Category: Eck, M J.]] | ||
[[Category: Harrison, S | [[Category: Harrison, S C.]] | ||
[[Category: Nolte, R | [[Category: Nolte, R T.]] | ||
[[Category: Schlessinger, J.]] | [[Category: Schlessinger, J.]] | ||
[[Category: Shoelson, S | [[Category: Shoelson, S E.]] | ||
[[Category: disease mutation]] | [[Category: disease mutation]] | ||
[[Category: p85]] | [[Category: p85]] | ||
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[[Category: ubl conjugation]] | [[Category: ubl conjugation]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:56:06 2008'' | ||
