3c06: Difference between revisions
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{{STRUCTURE_3c06| PDB=3c06 | SCENE= }} | {{STRUCTURE_3c06| PDB=3c06 | SCENE= }} | ||
===Lactobacillus CASEI Thymidylate Synthase Ternary Complex With DUMP and the Phtalimidic Derivative 14C in Multiple Binding Modes-Mode 1=== | ===Lactobacillus CASEI Thymidylate Synthase Ternary Complex With DUMP and the Phtalimidic Derivative 14C in Multiple Binding Modes-Mode 1=== | ||
{{ABSTRACT_PUBMED_21696158}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TYSY_LACCA TYSY_LACCA]] Provides the sole de novo source of dTMP for DNA biosynthesis. | |||
==About this Structure== | ==About this Structure== | ||
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==See Also== | ==See Also== | ||
*[[Thymidylate synthase|Thymidylate synthase]] | *[[Thymidylate synthase|Thymidylate synthase]] | ||
==Reference== | |||
<ref group="xtra">PMID:021696158</ref><references group="xtra"/><references/> | |||
[[Category: Lactobacillus casei]] | [[Category: Lactobacillus casei]] | ||
[[Category: Thymidylate synthase]] | [[Category: Thymidylate synthase]] | ||
Revision as of 14:18, 24 July 2013
Lactobacillus CASEI Thymidylate Synthase Ternary Complex With DUMP and the Phtalimidic Derivative 14C in Multiple Binding Modes-Mode 1Lactobacillus CASEI Thymidylate Synthase Ternary Complex With DUMP and the Phtalimidic Derivative 14C in Multiple Binding Modes-Mode 1
Template:ABSTRACT PUBMED 21696158
FunctionFunction
[TYSY_LACCA] Provides the sole de novo source of dTMP for DNA biosynthesis.
About this StructureAbout this Structure
3c06 is a 1 chain structure with sequence from Lactobacillus casei. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ Mangani S, Cancian L, Leone R, Pozzi C, Lazzari S, Luciani R, Ferrari S, Costi MP. Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening. J Med Chem. 2011 Aug 11;54(15):5454-67. Epub 2011 Jul 12. PMID:21696158 doi:10.1021/jm2005018