3n5e: Difference between revisions
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{{STRUCTURE_3n5e| PDB=3n5e | SCENE= }} | {{STRUCTURE_3n5e| PDB=3n5e | SCENE= }} | ||
===Crystal Structure of human thymidylate synthase bound to a peptide inhibitor=== | ===Crystal Structure of human thymidylate synthase bound to a peptide inhibitor=== | ||
{{ABSTRACT_PUBMED_21795601}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TYSY_HUMAN TYSY_HUMAN]] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.<ref>PMID:21876188</ref> | |||
==About this Structure== | ==About this Structure== | ||
| Line 11: | Line 11: | ||
==See Also== | ==See Also== | ||
*[[Thymidylate synthase|Thymidylate synthase]] | *[[Thymidylate synthase|Thymidylate synthase]] | ||
==Reference== | |||
<ref group="xtra">PMID:021795601</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Thymidylate synthase]] | [[Category: Thymidylate synthase]] | ||
Revision as of 14:11, 24 July 2013
Crystal Structure of human thymidylate synthase bound to a peptide inhibitorCrystal Structure of human thymidylate synthase bound to a peptide inhibitor
Template:ABSTRACT PUBMED 21795601
FunctionFunction
[TYSY_HUMAN] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.[1]
About this StructureAbout this Structure
3n5e is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ Cardinale D, Guaitoli G, Tondi D, Luciani R, Henrich S, Salo-Ahen OM, Ferrari S, Marverti G, Guerrieri D, Ligabue A, Frassineti C, Pozzi C, Mangani S, Fessas D, Guerrini R, Ponterini G, Wade RC, Costi MP. Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase. Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):E542-9. doi:, 10.1073/pnas.1104829108. Epub 2011 Jul 27. PMID:21795601 doi:10.1073/pnas.1104829108
- ↑ Anderson DD, Quintero CM, Stover PJ. Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15163-8. doi:, 10.1073/pnas.1103623108. Epub 2011 Aug 26. PMID:21876188 doi:10.1073/pnas.1103623108