NF-kB: Difference between revisions
Michal Harel (talk | contribs) New page: <StructureSection load='1scv' size='350' side='right' caption='Structure of human NF-kB1 p50 complex with DNA (PDB entry 1scv)' scene=''> '''NF-kB''' or '''Nuclear Factor NF-kappa... |
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<StructureSection load='1nfk' size='350' side='right' caption='Structure of human NF-kB1 p50 complex with DNA (PDB entry [[1nfk]])' scene=''> | |||
<StructureSection load=' | |||
'''NF-kB''' or '''Nuclear Factor NF-kappa''' is a DNA transcription factor. It is involved in cellular response to stimuli. NF-kB contains a Rel homology domain (RHR) which contains 2 immunoglobulin-like subdomains which interact with the major groove of DNA. There are 5 proteins in the NF-kB family: '''NF-kB1''' (synthesized as '''p105''' and processed to '''p50'''), '''NF-kB2''' (synthesized as '''p100''' and processed to '''p52'''), '''RelA''' (or '''p65'''), '''RelB''' and '''cRel'''. I-κ-B-α is an inhibitor of NF-kB. | '''NF-kB''' or '''Nuclear Factor NF-kappa''' is a DNA transcription factor. It is involved in cellular response to stimuli. NF-kB contains a Rel homology domain (RHR) which contains 2 immunoglobulin-like subdomains which interact with the major groove of DNA. There are 5 proteins in the NF-kB family: '''NF-kB1''' (synthesized as '''p105''' and processed to '''p50'''), '''NF-kB2''' (synthesized as '''p100''' and processed to '''p52'''), '''RelA''' (or '''p65'''), '''RelB''' and '''cRel'''. I-κ-B-α is an inhibitor of NF-kB. | ||
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'''NF-kB1 (p50)''' | '''NF-kB1 (p50)''' | ||
[[1svc]] – hp50 + DNA - human<br /> | [[1svc]] – hp50 + DNA - human - NMR<br /> | ||
[[1nfk]] – mp50 + DNA<br /> | [[1nfk]] – mp50 + DNA<br /> | ||
[[1bfs]] – mp50 dimerization domain<br /> | [[1bfs]] – mp50 dimerization domain<br /> | ||