2ihq: Difference between revisions
New page: left|200px<br /><applet load="2ihq" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ihq, resolution 2.00Å" /> '''Crystal Structure of... |
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[[Image:2ihq.jpg|left|200px]]<br /><applet load="2ihq" size=" | [[Image:2ihq.jpg|left|200px]]<br /><applet load="2ihq" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="2ihq, resolution 2.00Å" /> | caption="2ihq, resolution 2.00Å" /> | ||
'''Crystal Structure of the Rat Androgen Receptor Ligand Binding Domian Complex with an N-Aryl-Hydroxybicyclohydantoin'''<br /> | '''Crystal Structure of the Rat Androgen Receptor Ligand Binding Domian Complex with an N-Aryl-Hydroxybicyclohydantoin'''<br /> | ||
==Overview== | ==Overview== | ||
A novel, N-aryl-bicyclohydantoin selective androgen receptor modulator | A novel, N-aryl-bicyclohydantoin selective androgen receptor modulator scaffold was discovered through structure-guided modifications of androgen receptor antagonists. A prototype compound (7R,7aS)-10b from this series is a potent and highly tissue-selective agonist of the androgen receptor. After oral dosing in a rat atrophied levator ani muscle model, (7R,7aS)-10b demonstrated efficacy at restoring levator ani muscle mass to that of intact controls and exhibited >50-fold selectivity for muscle over prostate. | ||
==About this Structure== | ==About this Structure== | ||
2IHQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with LG7 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 2IHQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=LG7:'>LG7</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IHQ OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Sack, J | [[Category: Sack, J S.]] | ||
[[Category: LG7]] | [[Category: LG7]] | ||
[[Category: androgen receptor]] | [[Category: androgen receptor]] | ||
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[[Category: transcription regulation]] | [[Category: transcription regulation]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:52:53 2008'' | ||
