4lg2: Difference between revisions
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{{STRUCTURE_4lg2| PDB=4lg2 | SCENE= }} | |||
===Crystal structure of Reston Ebola virus VP35 RNA binding domain bound to 12-bp dsRNA=== | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/VP35_EBORR VP35_EBORR]] Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (By similarity). | |||
==About this Structure== | |||
[[4lg2]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Reston_ebolavirus_-_reston_(1989) Reston ebolavirus - reston (1989)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LG2 OCA]. | |||
[[Category: Bale, S.]] | |||
[[Category: Bornholdt, Z A.]] | |||
[[Category: E O., Saphire..]] | |||
[[Category: Julien, J-P.]] | |||
[[Category: Krois, A S.]] | |||
[[Category: Wilson, I A.]] | |||
[[Category: Dsrna]] | |||
[[Category: Dsrna binding protein]] | |||
[[Category: Rna binding domain]] | |||
[[Category: Rna binding protein-rna complex]] | |||
Revision as of 18:57, 10 July 2013
Crystal structure of Reston Ebola virus VP35 RNA binding domain bound to 12-bp dsRNACrystal structure of Reston Ebola virus VP35 RNA binding domain bound to 12-bp dsRNA
FunctionFunction
[VP35_EBORR] Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (By similarity).
About this StructureAbout this Structure
4lg2 is a 8 chain structure with sequence from Reston ebolavirus - reston (1989). Full crystallographic information is available from OCA.