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==Overview== | ==Overview== | ||
This paper describes the structure determination of nsp3a, the N-terminal | This paper describes the structure determination of nsp3a, the N-terminal domain of the severe acute respiratory syndrome coronavirus (SARS-CoV) nonstructural protein 3. nsp3a exhibits a ubiquitin-like globular fold of residues 1 to 112 and a flexibly extended glutamic acid-rich domain of residues 113 to 183. In addition to the four beta-strands and two alpha-helices that are common to ubiquitin-like folds, the globular domain of nsp3a contains two short helices representing a feature that has not previously been observed in these proteins. Nuclear magnetic resonance chemical shift perturbations showed that these unique structural elements are involved in interactions with single-stranded RNA. Structural similarities with proteins involved in various cell-signaling pathways indicate possible roles of nsp3a in viral infection and persistence. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Sars coronavirus]] | [[Category: Sars coronavirus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Almeida, M | [[Category: Almeida, M S.]] | ||
[[Category: Herrmann, T.]] | [[Category: Herrmann, T.]] | ||
[[Category: Horst, R.]] | [[Category: Horst, R.]] | ||
[[Category: JCSG, Joint | [[Category: JCSG, Joint Center for Structural Genomics.]] | ||
[[Category: Johnson, M | [[Category: Johnson, M A.]] | ||
[[Category: Joseph, J.]] | [[Category: Joseph, J.]] | ||
[[Category: Kuhn, P.]] | [[Category: Kuhn, P.]] | ||
[[Category: Saikatendu, K.]] | [[Category: Saikatendu, K.]] | ||
[[Category: Serrano, P.]] | [[Category: Serrano, P.]] | ||
[[Category: Stevens, R | [[Category: Stevens, R C.]] | ||
[[Category: Subramanian, V.]] | [[Category: Subramanian, V.]] | ||
[[Category: Wuthrich, K.]] | [[Category: Wuthrich, K.]] | ||
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[[Category: viral protein]] | [[Category: viral protein]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:51:38 2008'' | ||