4fse: Difference between revisions
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{{STRUCTURE_4fse| PDB=4fse | SCENE= }} | {{STRUCTURE_4fse| PDB=4fse | SCENE= }} | ||
===crystal structure of beta-site app-cleaving enzyme 1 (bace-wt) complex with N-(N-(4-amino-3,5- dichlorobenzyl)carbamimidoyl)-3-(4-methoxyphenyl)-5- methyl-4-isothiazolecarboxamide=== | ===crystal structure of beta-site app-cleaving enzyme 1 (bace-wt) complex with N-(N-(4-amino-3,5- dichlorobenzyl)carbamimidoyl)-3-(4-methoxyphenyl)-5- methyl-4-isothiazolecarboxamide=== | ||
{{ABSTRACT_PUBMED_23030502}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[4fse]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FSE OCA]. | [[4fse]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FSE OCA]. | ||
==See Also== | |||
*[[Beta secretase|Beta secretase]] | |||
==Reference== | |||
<ref group="xtra">PMID:023030502</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Memapsin 2]] | [[Category: Memapsin 2]] | ||
[[Category: Muckelbauer, J K.]] | [[Category: Muckelbauer, J K.]] | ||