3u10: Difference between revisions
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{{STRUCTURE_3u10| PDB=3u10 | SCENE= }} | {{STRUCTURE_3u10| PDB=3u10 | SCENE= }} | ||
===Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN channels=== | ===Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN channels=== | ||
{{ABSTRACT_PUBMED_22006928}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/HCN2_HUMAN HCN2_HUMAN]] Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages (By similarity). | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:022006928</ref><references group="xtra"/> | <ref group="xtra">PMID:022006928</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrigoni, C.]] | [[Category: Arrigoni, C.]] |