4ixg: Difference between revisions
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==About this Structure== | ==About this Structure== | ||
[[4ixg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pneumocystis_carinii Pneumocystis carinii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IXG OCA]. | [[4ixg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pneumocystis_carinii Pneumocystis carinii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IXG OCA]. | ||
==Reference== | |||
<ref group="xtra">PMID:023627352</ref><references group="xtra"/><references/> | |||
[[Category: Dihydrofolate reductase]] | [[Category: Dihydrofolate reductase]] | ||
[[Category: Pneumocystis carinii]] | [[Category: Pneumocystis carinii]] | ||
Revision as of 17:23, 10 July 2013
pcDHFR-268-K37S-N69F variantpcDHFR-268-K37S-N69F variant
Template:ABSTRACT PUBMED 23627352
FunctionFunction
[DYR_PNECA] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
About this StructureAbout this Structure
4ixg is a 1 chain structure with sequence from Pneumocystis carinii. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Gangjee A, Namjoshi OA, Raghavan S, Queener SF, Kisliuk RL, Cody V. Design, synthesis and molecular modeling of novel pyrido[2,3-d]pyrimidine analogs as antifolates: Application of Buchwald-Hartwig aminations of heterocycles. J Med Chem. 2013 Apr 29. PMID:23627352 doi:10.1021/jm400086g