3u3s: Difference between revisions
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{{STRUCTURE_3u3s| PDB=3u3s | SCENE= }} | |||
===The S-SAD phased crystal structure of the ecto-domain of Death Receptor 6 (DR6)=== | |||
{{ABSTRACT_PUBMED_22525750}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TNR21_HUMAN TNR21_HUMAN]] May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). | |||
==About this Structure== | |||
[[3u3s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U3S OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:022525750</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Ding, W.]] | |||
[[Category: Hung, L W.]] | |||
[[Category: Jiao, L Y.]] | |||
[[Category: Liu, Z J.]] | |||
[[Category: Matsugaki, N.]] | |||
[[Category: Ru, H.]] | |||
[[Category: Shaw, N.]] | |||
[[Category: Wakatsuki, S.]] | |||
[[Category: Zhang, L G.]] | |||
[[Category: Zhao, L X.]] | |||
[[Category: Apoptosis]] | |||
[[Category: Trigger apoptosis]] | |||
Revision as of 17:23, 10 July 2013
The S-SAD phased crystal structure of the ecto-domain of Death Receptor 6 (DR6)The S-SAD phased crystal structure of the ecto-domain of Death Receptor 6 (DR6)
Template:ABSTRACT PUBMED 22525750
FunctionFunction
[TNR21_HUMAN] May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
About this StructureAbout this Structure
3u3s is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Ru H, Zhao L, Ding W, Jiao L, Shaw N, Liang W, Zhang L, Hung LW, Matsugaki N, Wakatsuki S, Liu ZJ. S-SAD phasing study of death receptor 6 and its solution conformation revealed by SAXS. Acta Crystallogr D Biol Crystallogr. 2012 May;68(Pt 5):521-30. Epub 2012 Apr 17. PMID:22525750 doi:10.1107/S0907444912004490