G1SecL05: Difference between revisions
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===Structure of LA-2 OspA complex === | ===Structure of LA-2 OspA complex === | ||
<Structure load='1FJ1' size='400' frame='true' align='center' scene='Studio:G1SecL01/2/1' / caption='Outer'> | <Structure load='1FJ1' size='400' frame='true' align='center' scene='Studio:G1SecL01/2/1' / caption='Outer surface protein A complex with antibody (PDB code [[1fj1]])'> | ||
<scene name='Studio:G1SecL01/2/1'>Initial Scene</scene>---<scene name='Studio:G1SecL01/2/2'>Three Loops</scene> | <scene name='Studio:G1SecL01/2/1'>Initial Scene</scene>---<scene name='Studio:G1SecL01/2/2'>Three Loops</scene> | ||
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Although the LA-2- ospA complex induces a high reactivity of protective immune response for ''B. burgdorferi'', it lacks the broad specificity to encompass other genospecies of ''Borrelia''. In North America, Lyme borreliosis is caused by a single strain ''B.burgdorferi'', whereas in parts of Europe and Asia, a minimum of three strains, ''B. afzelli'', ''B. burgdorferi'', and ''B. garinii'' are involved in infecting humans<ref>PMID: 21217174</ref>. The lack of broad specificity in the LA-2- OspA complex is due to the presence of highly variable regions in ospA. | Although the LA-2- ospA complex induces a high reactivity of protective immune response for ''B. burgdorferi'', it lacks the broad specificity to encompass other genospecies of ''Borrelia''. In North America, Lyme borreliosis is caused by a single strain ''B.burgdorferi'', whereas in parts of Europe and Asia, a minimum of three strains, ''B. afzelli'', ''B. burgdorferi'', and ''B. garinii'' are involved in infecting humans<ref>PMID: 21217174</ref>. The lack of broad specificity in the LA-2- OspA complex is due to the presence of highly variable regions in ospA. | ||
<Structure load='1fj1' size='450' frame='true' align='right' caption=' | <Structure load='1fj1' size='450' frame='true' align='right' caption='Outer surface protein A (magenta and cyan) complex with antibody light chain (grey and pink) and heavy chain (green and yellow) (PDB code [[1fj1]]) ' | ||
scene='Insert optional scene name here' /> | scene='Insert optional scene name here' /> | ||
<scene name='G1SecL05/1fj1_chains_labeled/4'>Label All Chains</scene>---<scene name='G1SecL05/1fj1-condensed/5'>Show Only Chain E</scene>---<scene name='G1SecL05/1fj1-condensed/3'>Close up view</scene> | <scene name='G1SecL05/1fj1_chains_labeled/4'>Label All Chains</scene>---<scene name='G1SecL05/1fj1-condensed/5'>Show Only Chain E</scene>---<scene name='G1SecL05/1fj1-condensed/3'>Close up view</scene> | ||