4kpq: Difference between revisions
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{{STRUCTURE_4kpq| PDB=4kpq | SCENE= }} | |||
===Structure and receptor binding specificity of the hemagglutinin H13 from avian influenza A virus H13N6=== | |||
{{ABSTRACT_PUBMED_23760233}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/HEMA_I77AF HEMA_I77AF]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore. | |||
==About this Structure== | |||
[[4kpq]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/gull/maryland/704/1977(h13n6)) Influenza a virus (a/gull/maryland/704/1977(h13n6))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KPQ OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023760233</ref><references group="xtra"/><references/> | |||
[[Category: Gao, G.]] | |||
[[Category: Lu, X.]] | |||
[[Category: Qi, J.]] | |||
[[Category: Shi, Y.]] | |||
[[Category: Receptor binding]] | |||
[[Category: Viral protein]] | |||
Revision as of 17:07, 3 July 2013
Structure and receptor binding specificity of the hemagglutinin H13 from avian influenza A virus H13N6Structure and receptor binding specificity of the hemagglutinin H13 from avian influenza A virus H13N6
Template:ABSTRACT PUBMED 23760233
FunctionFunction
[HEMA_I77AF] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.
About this StructureAbout this Structure
4kpq is a 6 chain structure with sequence from Influenza a virus (a/gull/maryland/704/1977(h13n6)). Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Lu X, Qi J, Shi Y, Wang M, Smith DF, Heimburg-Molinaro J, Zhang Y, Paulson JC, Xiao H, Gao GF. Structure and receptor binding specificity of the hemagglutinin H13 from avian influenza A virus H13N6. J Virol. 2013 Jun 12. PMID:23760233 doi:10.1128/JVI.00235-13