4ke1: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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-'''Unreleased structure'''
+{{STRUCTURE_4ke1|  PDB=4ke1  |  SCENE=  }}
+===Crystal structure of BACE1 in complex with hydroxyethylamine-macrocyclic inhibitor 19===
+{{ABSTRACT_PUBMED_23769639}}
-The entry 4ke1 is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
-Authors: Whittington, D.A., Long, A.M., Li, V.
+==About this Structure==
+[[4ke1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KE1 OCA].
-Description: Crystal structure of BACE1 in complex with hydroxyethylamine-macrocyclic inhibitor 19
+==Reference==
+<ref group="xtra">PMID:023769639</ref><references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Memapsin 2]]
+[[Category: Li, V.]]
+[[Category: Long, A M.]]
+[[Category: Whittington, D A.]]
+[[Category: Alzheimer's disease]]
+[[Category: Aspartic protease]]
+[[Category: Hydrolase-hydrolase inhibitor complex]]