4bnc: Difference between revisions
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{{STRUCTURE_4bnc| PDB=4bnc | SCENE= }} | |||
===Crystal structure of the DNA-binding domain of human ETV1 complexed with DNA=== | |||
The entry | ==Disease== | ||
[[http://www.uniprot.org/uniprot/ETV1_HUMAN ETV1_HUMAN]] Ewing sarcoma. Ewing sarcoma (ES) [MIM:[http://omim.org/entry/612219 612219]]: A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving ETV1 is found in patients with Erwing sarcoma. Translocation t(7;22)(p22;q12) with EWSR1. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ETV1_HUMAN ETV1_HUMAN]] Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'. | |||
==About this Structure== | |||
[[4bnc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4b06 4b06]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BNC OCA]. | |||
[[Category: Homo sapiens]] | |||
[[Category: Allerston, C K.]] | |||
[[Category: Arrowsmith, C H.]] | |||
[[Category: Bountra, C.]] | |||
[[Category: Chaikuad, A.]] | |||
[[Category: Cooper, C D.O.]] | |||
[[Category: Delft, F von.]] | |||
[[Category: Edwards, A.]] | |||
[[Category: Froese, D S.]] | |||
[[Category: Gileadi, O.]] | |||
[[Category: Krojer, T.]] | |||
[[Category: Vollmar, M.]] | |||
[[Category: Dna-binding protein]] | |||
Revision as of 16:57, 3 July 2013
Crystal structure of the DNA-binding domain of human ETV1 complexed with DNACrystal structure of the DNA-binding domain of human ETV1 complexed with DNA
DiseaseDisease
[ETV1_HUMAN] Ewing sarcoma. Ewing sarcoma (ES) [MIM:612219]: A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving ETV1 is found in patients with Erwing sarcoma. Translocation t(7;22)(p22;q12) with EWSR1.
FunctionFunction
[ETV1_HUMAN] Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'.
About this StructureAbout this Structure
4bnc is a 3 chain structure with sequence from Homo sapiens. This structure supersedes the now removed PDB entry 4b06. Full crystallographic information is available from OCA.