1uxb: Difference between revisions
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Revision as of 17:09, 30 October 2007
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ADENOVIRUS AD19P FIBRE HEAD IN COMPLEX WITH SIALYL-LACTOSE
OverviewOverview
Adenovirus serotype 37 (Ad37) belongs to species D and can cause epidemic, keratoconjunctivitis, whereas the closely related Ad19p does not. Primary, cell attachment by adenoviruses is mediated through receptor binding of, the knob domain of the fiber protein. The knobs of Ad37 and Ad19p differ, at only two positions, Lys240Glu and Asn340Asp. We report the, high-resolution crystal structures of the Ad37 and Ad19p knobs, both, native and in complex with sialic acid, which has been proposed as a, receptor for Ad37. Overall, the Ad37 and Ad19p knobs are very similar to, previously reported knob structures, especially to that of Ad5, which, binds the coxsackievirus-adenovirus receptor (CAR). Ad37 and Ad19p knobs, are structurally identical with the exception of the changed side chains, and ... [(full description)]
About this StructureAbout this Structure
1UXB is a [Single protein] structure of sequence from [Human adenovirus type 15] with ZN and ACT as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
Crystal structure of species D adenovirus fiber knobs and their sialic acid binding sites., Burmeister WP, Guilligay D, Cusack S, Wadell G, Arnberg N, J Virol. 2004 Jul;78(14):7727-36. PMID:15220447
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