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New page: left|200px<br /> <applet load="2i0h" size="450" color="white" frame="true" align="right" spinBox="true" caption="2i0h, resolution 2.00Å" /> '''The structure of p3... |
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[[Image:2i0h.gif|left|200px]]<br /> | [[Image:2i0h.gif|left|200px]]<br /><applet load="2i0h" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="2i0h" size=" | |||
caption="2i0h, resolution 2.00Å" /> | caption="2i0h, resolution 2.00Å" /> | ||
'''The structure of p38alpha in complex with an arylpyridazinone'''<br /> | '''The structure of p38alpha in complex with an arylpyridazinone'''<br /> | ||
==Overview== | ==Overview== | ||
p38 inhibitors based on 3,4-dihydropyrido[4,3-d]pyrimidazin-2-one template | p38 inhibitors based on 3,4-dihydropyrido[4,3-d]pyrimidazin-2-one template were synthesized and their SAR explored. Benchmark compounds 30, 35, and 36 were found to be potent against the enzyme. Crystal structure of p38 in complex with 30 indicated a key pi-stacking interaction with the pendant tyrosine residue-35 in the glycine-rich loop. | ||
==About this Structure== | ==About this Structure== | ||
2I0H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with 222 and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] Full crystallographic information is available from [http:// | 2I0H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=222:'>222</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I0H OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Mitogen-activated protein kinase]] | [[Category: Mitogen-activated protein kinase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Fitzgerald, C | [[Category: Fitzgerald, C E.]] | ||
[[Category: Heller, S | [[Category: Heller, S T.]] | ||
[[Category: Keefe, S | [[Category: Keefe, S J.O.]] | ||
[[Category: Nam, K.]] | [[Category: Nam, K.]] | ||
[[Category: Natarajan, S | [[Category: Natarajan, S R.]] | ||
[[Category: Patel, S.]] | [[Category: Patel, S.]] | ||
[[Category: Scapin, G.]] | [[Category: Scapin, G.]] | ||
[[Category: Singh, S | [[Category: Singh, S B.]] | ||
[[Category: Thompson, J | [[Category: Thompson, J E.]] | ||
[[Category: 222]] | [[Category: 222]] | ||
[[Category: GOL]] | [[Category: GOL]] | ||
| Line 29: | Line 28: | ||
[[Category: serine/threonine kinase]] | [[Category: serine/threonine kinase]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:47:43 2008'' | ||
Revision as of 18:47, 21 February 2008
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The structure of p38alpha in complex with an arylpyridazinone
OverviewOverview
p38 inhibitors based on 3,4-dihydropyrido[4,3-d]pyrimidazin-2-one template were synthesized and their SAR explored. Benchmark compounds 30, 35, and 36 were found to be potent against the enzyme. Crystal structure of p38 in complex with 30 indicated a key pi-stacking interaction with the pendant tyrosine residue-35 in the glycine-rich loop.
About this StructureAbout this Structure
2I0H is a Single protein structure of sequence from Homo sapiens with and as ligands. Active as Mitogen-activated protein kinase, with EC number 2.7.11.24 Full crystallographic information is available from OCA.
ReferenceReference
p38 MAP kinase inhibitors. Part 6: 2-arylpyridazin-3-ones as templates for inhibitor design., Natarajan SR, Heller ST, Nam K, Singh SB, Scapin G, Patel S, Thompson JE, Fitzgerald CE, O'Keefe SJ, Bioorg Med Chem Lett. 2006 Nov 15;16(22):5809-13. Epub 2006 Aug 30. PMID:16945533
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